Molecular Pathways: Reactive Oxygen Species Homeostasis in Cancer Cells and Implications for Cancer Therapy
Molecular Pathways: Reactive Oxygen Species Homeostasis in Cancer Cells and Implications for Cancer Therapy
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DOI：
10.1158/1078-0432.ccr-12-1424
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发表时间：
2013-08-15
影响因子：
11.5
通讯作者：
Hay, Nissim
中科院分区：
文献类型：
--
作者：
Nogueira, Veronique;Hay, Nissim
活性氧（ROS）对于调节正常细胞过程很重要，但活性氧失调会导致包括癌症在内的各种人类疾病的发生。与正常细胞相比，癌细胞由于新陈代谢加速，ROS 水平升高。癌细胞中高水平的活性氧（ROS）是它们与正常细胞的区别，可能具有促癌作用，但也是它们的致命弱点。癌细胞中的高活性氧含量使它们更容易受到氧化应激诱导的细胞死亡的影响，可用于选择性癌症治疗。在这篇综述中，我们描述了几种潜在的治疗策略，这些策略通过进一步增加氧化应激来利用癌细胞中的 ROS 不平衡，无论是单独使用还是与调节某些信号通路的药物联合使用。 (C)2013 AACR。
Reactive oxygen species (ROS) are important in regulating normal cellular processes, but deregulated ROS contribute to the development of various human diseases, including cancers. Cancer cells have increased ROS levels compared with normal cells, because of their accelerated metabolism. The high ROS levels in cancer cells, which distinguish them from normal cells, could be protumorigenic, but are also their Achilles' heel. The high ROS content in cancer cells renders them more susceptible to oxidative stress-induced cell death, and can be exploited for selective cancer therapy. In this review, we describe several potential therapeutic strategies that take advantage of ROS imbalance in cancer cells by further increasing oxidative stress, either alone or in combination with drugs that modulate certain signaling pathways. (C)2013 AACR.