Phytochrome B interacts with SWC6 and ARP6 to regulate H2A.Z deposition and photomorphogensis in Arabidopsis.
Phytochrome B interacts with SWC6 and ARP6 to regulate H2A.Z deposition and photomorphogensis in Arabidopsis.
复制标题
光敏色素 B 与 SWC6 和 ARP6 相互作用，调节拟南芥中的 H2A.Z 沉积和光形态发生。
DOI：
10.1111/jipb.13111
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发表时间：
2021-05
影响因子：
11.4
通讯作者：
Mao Zhilei
中科院分区：
文献类型：
--
作者：
Wei Xuxu;Wang Wanting;Xu Peng;Wang Wenxiu;Guo Tongtong;Kou Shuang;Liu Minqing;Niu Yake;Yang Hong-Quan;Mao Zhilei
Light serves as a crucial environmental cue that modulates plant growth and development, which is controlled by multiple photoreceptors including the primary red light photoreceptor, phytochrome B (phyB). The signaling mechanism of phyB involves direct interactions with a group of basic helix-loop-helix (bHLH) transcription factors, PHYTOCHROME-INTERACTING FACTORS (PIFs), and the negative regulators of photomorphogenesis, COP1 and SPAs. H2A.Z is an evolutionarily conserved H2A variant that plays essential roles in transcriptional regulation. The replacement of H2A with H2A.Z is catalyzed by the SWR1 complex. Here, we show that the Pfr form of phyB physically interacts with the SWR1 complex subunits SWC6 and ARP6. phyB and ARP6 co-regulate numerous genes in the same direction, some of which are associated with auxin biosynthesis and response including YUC9, which encodes a rate-limiting enzyme in the tryptophan-dependent auxin biosynthesis pathway. Moreover, phyB and HY5/HYH act to inhibit hypocotyl elongation partially through repression of auxin biosynthesis. Based our findings and previous studies, we propose that phyB promotes H2A.Z deposition at YUC9 to inhibit its expression through direct phyB-SWC6/ARP6 interactions, leading to repression of auxin biosynthesis, and thus inhibition of hypocotyl elongation in red light. This article is protected by copyright. All rights reserved.
