Acoustofluidic Synthesis of Particulate Nanomaterials
Acoustofluidic Synthesis of Particulate Nanomaterials
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DOI：
10.1002/advs.201900913
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发表时间：
2019-08-27
期刊：
影响因子：
15.1
通讯作者：
Huang, Tony Jun
中科院分区：
文献类型：
--
作者：
Huang, Po-Hsun;Zhao, Shuaiguo;Huang, Tony Jun
具有定制特性的纳米颗粒和颗粒纳米材料的合成是从能量转换和成像/显示到生物传感和纳米医学的许多应用的核心步骤。虽然现有的基于微流体的合成方法提供了对合成过程的精确控制，但它们中的大多数依赖于试剂的被动、部分混合，这限制了它们的适用性，并可能不利地改变合成产物的性质。这里，声流体（即，声学和微流体的融合）合成平台被报道通过基于声流的试剂的主动混合以可控的、可再现的方式合成纳米颗粒和纳米材料。声流控策略允许简单地通过调节声流的强度来动态控制反应条件。利用该平台，展示了多功能纳米颗粒/纳米材料的合成，包括聚合物纳米颗粒、壳聚糖纳米颗粒、有机-无机杂化纳米材料、金属-有机框架生物复合材料和脂质-DNA复合物的合成。声流体合成平台，当与不同的流速，成分或试剂浓度结合时，将在建立各种反应条件方面提供前所未有的灵活性，从而能够合成具有规定性质的通用纳米颗粒和纳米材料。
Synthesis of nanoparticles and particulate nanomaterials with tailored properties is a central step toward many applications ranging from energy conversion and imaging/display to biosensing and nanomedicine. While existing microfluidics-based synthesis methods offer precise control over the synthesis process, most of them rely on passive, partial mixing of reagents, which limits their applicability and potentially, adversely alter the properties of synthesized products. Here, an acoustofluidic (i.e., the fusion of acoustic and microfluidics) synthesis platform is reported to synthesize nanoparticles and nanomaterials in a controllable, reproducible manner through acoustic-streaming-based active mixing of reagents. The acoustofluidic strategy allows for the dynamic control of the reaction conditions simply by adjusting the strength of the acoustic streaming. With this platform, the synthesis of versatile nanoparticles/nanomaterials is demonstrated including the synthesis of polymeric nanoparticles, chitosan nanoparticles, organic-inorganic hybrid nanomaterials, metal-organic framework biocomposites, and lipid-DNA complexes. The acoustofluidic synthesis platform, when incorporated with varying flow rates, compositions, or concentrations of reagents, will lend itself unprecedented flexibility in establishing various reaction conditions and thus enable the synthesis of versatile nanoparticles and nanomaterials with prescribed properties.