Changes in natural killer cells, the CD57CD8 subset, and related cytokines in healthy aging
Changes in natural killer cells, the CD57CD8 subset, and related cytokines in healthy aging
复制标题
DOI：
10.1023/a:1023283719877
复制
发表时间：
1998-01-01
影响因子：
9.1
通讯作者：
Morris, TCM
中科院分区：
文献类型：
--
作者：
McNerlan, SE;Rea, IM;Morris, TCM
已有研究表明，衰老伴随着老年人淋巴细胞亚群分布的各种变化。我们在大量受试者中更全面地研究了几个携带自然杀伤(NK)细胞相关表面抗原的亚群中与年龄相关的变化，以及参与NK细胞增殖的几种细胞因子的变化。这项横断面研究包括了229名健康受试者，年龄从20岁到98岁不等。CD3-CD(16+56)+、CD3+CD(16+56)+、CD57+CD8+、CD57+CD8((Low))+和CD57+CD8-细胞的绝对数和比例均随年龄增加而显著增加，而CD57+CD8((High))+亚群随年龄变化较小。还提供了一些证据，表明这些扩增的NK细胞群处于激活状态。可溶性IL-2受体水平也随着年龄的增长而显著升高，并与某些NK细胞亚群相关。尽管其中一些亚群的功能仍有待阐明，但它们在老年人中的扩张可能代表着随着年龄的增长免疫系统的重塑，非MHC限制性细胞的增加可能弥补了先前报道的老年人T和B细胞的下降。或者，这些细胞数量的增加可能是细胞因子失调或抗原或肿瘤细胞挑战增加的直接结果。
Aging has been shown to be accompanied by various changes in the lymphocyte subset distribution in the elderly. We have investigated more fully, and in a large number of subjects, age-related changes within several subpopulations bearing natural killer (NK) cell-associated surface antigens and changes in several cytokines involved in NK cell expansion. A total of 229 healthy subjects from all decades of life from 20 to 98 years of age was included in this cross-sectional study. A significant increase with age was found in both the absolute counts and the proportions of CD3-CD(16+56)+, CD3+CD(16+56)+, CD57+CD8+, CD57+CD8((low))+, and CD57+CD8- cells, whereas the CD57+CD8((high))+ subset, which may represent the cytolytic T cell population more precisely, showed less change with age. Some evidence is also provided to suggest that these expanded NK cell populations are in an activated state. Soluble IL-2 receptor levels were also found to increase significantly with age and correlated with certain NK cell subsets. Although the functions of some of these subsets remain to be elucidated, their expansion in the elderly may represent a remodeling of the immune system with increasing age, with an increase in non-MHC-restricted cells perhaps compensating for the previously reported decline in T and B cells in the elderly. Alternatively, increased numbers of these cells may be a direct result of cytokine dysregulation or increased antigenic or neoplastic cell challenge.