MicroRNAs in immune regulation--opportunities for cancer immunotherapy.
MicroRNAs in immune regulation--opportunities for cancer immunotherapy.
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DOI：
10.1016/j.biocel.2010.02.002
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发表时间：
2010-08
影响因子：
4
通讯作者：
Lotze, Michael T.
中科院分区：
文献类型：
--
作者：
Okada, Hideho;Kohanbash, Gary;Lotze, Michael T.
据预测，内源性产生的microRNA调节超过三分之二的人类基因转录物的翻译。某些microRNA调节基因的表达，这些基因在先天性和适应性免疫应答中起关键作用。免疫细胞是microRNA基因治疗方法的一个非常有吸引力的靶点，因为这些细胞可以被分离、处理，然后重新引入患者体内。在这篇简短的综述中，我们讨论了最近发现的microRNA在免疫调节中的作用将如何推动癌症免疫学和免疫治疗领域的发展。已经在T细胞中鉴定的靶标包括microRNA、miR-17-92家族、miR-155和miR-181 a。在巨噬细胞中，miR-125 b、miR-146和miR-155充当病原体相关分子模式分子相关microRNA，而miR-34 C和miR-214充当损伤相关分子模式分子相关miR。我们还证明了肿瘤作为细胞溶解效应物靶点的能力受miR-222和miR-339的调节。
Endogenously produced microRNAs are predicted to regulate the translation of over two-thirds all human gene transcripts. Certain microRNAs regulate expression of genes that are critically involved in both innate and adaptive immune responses. Immune cells represent a highly attractive target for microRNA gene therapy approaches, as these cells can be isolated, treated and then reintroduced into the patient. In this short review, we discuss how recent discoveries on the roles of microRNAs in immune-regulation will advance the field of cancer immunology and immunotherapy. Targets identified already in T cells include microRNAs, miR-17-92 family, miR-155, and miR-181a. In macrophages, miR-125b, miR-146, and miR-155 act as Pathogen Associated Molecular Pattern Molecule-associated microRNAs and miR-34C and miR-214 as Damage Associated Molecular Pattern Molecules-associated miRs. We have also demonstrated that the ability of tumors to serve as targets for cytolytic effectors is regulated by miR-222 and miR-339.
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DOI：
10.1084/jem.20061692
发表时间：
2006-10-30
期刊：
The Journal of experimental medicine
影响因子：
--
作者：
Cobb BS;Hertweck A;Smith J;O'Connor E;Graf D;Cook T;Smale ST;Sakaguchi S;Livesey FJ;Fisher AG;Merkenschlager M
通讯作者：
Merkenschlager M
影响因子：
20.3
作者：
Eltzschig, HK;Thompson, LF;Colgan, SP
通讯作者：
Colgan, SP
影响因子：
4.5
作者：
Chen JL;Lucas JE;Schroeder T;Mori S;Wu J;Nevins J;Dewhirst M;West M;Chi JT
通讯作者：
Chi JT
DOI：
10.1056/nejmoa0901282
发表时间：
2009-10-08
期刊：
The New England journal of medicine
影响因子：
--
作者：
Ji J;Shi J;Budhu A;Yu Z;Forgues M;Roessler S;Ambs S;Chen Y;Meltzer PS;Croce CM;Qin LX;Man K;Lo CM;Lee J;Ng IO;Fan J;Tang ZY;Sun HC;Wang XW
通讯作者：
Wang XW
影响因子：
20.3
作者：
Inomata, Mika;Tagawa, Hiroyuki;Sawada, Kenichi
通讯作者：
Sawada, Kenichi