Effect of food composition on vitamin K absorption in human volunteers
Effect of food composition on vitamin K absorption in human volunteers
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DOI：
10.1079/bjn19960027
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发表时间：
1996-08-01
影响因子：
3.6
通讯作者：
Vermeer, C
中科院分区：
文献类型：
--
作者：
Gijsbers, BLM;Jie, KSG;Vermeer, C
人体对维生素K的需求量并不精确，但通常认为最低需求量在0.5至1 × 10（-6）g/kg体重之间。在本研究中，我们解决了循环维生素K浓度受维生素摄入形式影响的程度。实验组由5名健康志愿者组成，他们在禁食过夜后接受叶绿醌，在连续三周的第一天，参与者消耗了1毫克（2.2 pmol）叶绿醌，其为药物制剂的形式（Konakion（R）），或以菠菜+黄油的形式，或作为没有添加脂肪的菠菜，菠菜加黄油和不加黄油后循环叶绿醌水平显著降低（分别为服用药物浓缩物后的7.5倍和24.3倍），此外，从蔬菜中吸收叶绿醌比从Konakion中吸收慢1.5倍，在同样的五名志愿者的第二个实验中，显示在食用富含这种维生素的黄油后，相对大量的甲基萘醌-4进入循环，结论是膜结合叶绿醌的生物利用率极低，可能取决于其他食物成分，特别是脂肪。（叶醌+甲基萘醌）低于一般假设，并取决于维生素摄入的形式，这些新的见解可能会导致对维生素K推荐每日摄入量的修订。
The human vitamin K requirement is not known precisely, but the minimal requirement is often assumed to be between 0.5 and 1 x 10(-6) g/kg body weight, In the present study we addressed the question to what extent circulating vitamin K concentrations are influenced by the form in which the vitamer is consumed, The experimental group consisted of five healthy volunteers who received phylloquinone after an overnight fast, On the first day of three successive weeks the participants consumed I mg (2.2 pmol) phylloquinone, either in the form of a pharmaceutical preparation (Konakion(R)), or in the form of spinach + butter, or as spinach without added fat, Circulating phylloquinone levels after spinach with and without butter were substantially lower (7.5- and 24.3-fold respectively) than those after taking the pharmaceutical concentrate, Moreover, the absorption of phylloquinone from the vegetables was 1.5 times slower than from Konakion, In a second experiment in the same five volunteers it was shown that relatively high amounts of menaquinone-4 enter the circulation after the consumption of butter enriched with this vitamer, It is concluded that the bioavailability of membrane-bound phylloquinone is extremely poor and may depend on other food components, notably fat, The bioavailability of dietary vitamin K (phylloquinone + menaquinones) is lower than generally assumed, and depends on the form in which the vitamin is ingested, These new insights may lead to a revision of the recommended daily intake for vitamin K.