A Wearable Optical Microfibrous Biomaterial with Encapsulated Nanosensors Enables Wireless Monitoring of Oxidative Stress
A Wearable Optical Microfibrous Biomaterial with Encapsulated Nanosensors Enables Wireless Monitoring of Oxidative Stress
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DOI：
10.1002/adfm.202006254
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发表时间：
2021-01-15
影响因子：
19
通讯作者：
Roxbury, Daniel
中科院分区：
文献类型：
--
作者：
Safaee, Mohammad Moein;Gravely, Mitchell;Roxbury, Daniel
为了促进个性化的医疗方法，使用可穿戴技术对生化信息进行持续和非侵入性的监测可以使人们能够详细了解个人的生理状况。活性氧(ROS)是一类在多种生物过程中发挥作用的含氧自由基。在伤口愈合应用中，通过可穿戴诊断平台持续监测ROS对于预防慢性和病原性感染至关重要。在这里，利用通用的一步法来制备含有单壁碳纳米管(SWCNTs)的光学核壳微纤维纺织品，用于实时光学监测体外伤口中的过氧化氢浓度。SWCNTs对环境敏感且不可漂白的荧光使其能够连续监测分析物，而信号不会随着时间的推移而衰减。由于单壁碳纳米管发射的近红外窄带荧光的多个手性的存在，使得读出的信号与激发源距离和曝光时间保持不变。单独的纤维包裹SWCNT纳米传感器至少21天，没有明显的结构完整性损失。此外，微纤维纺织品被用来使用照相机在空间上分解过氧化氢浓度，并进一步集成到商业伤口绷带中，而不会显著降低其光学性能。
In an effort to facilitate personalized medical approaches, the continuous and noninvasive monitoring of biochemical information using wearable technologies can enable a detailed understanding of an individual's physiology. Reactive oxygen species (ROS) are a class of oxygen-containing free radicals that function in a wide range of biological processes. In wound healing applications, the continuous monitoring of ROS through a wearable diagnostics platform is essential for the prevention of chronicity and pathogenic infection. Here, a versatile one-step procedure is utilized to fabricate optical core-shell microfibrous textiles incorporating single-walled carbon nanotubes (SWCNTs) for the real-time optical monitoring of hydrogen peroxide concentrations in in vitro wounds. The environmentally sensitive and non-photobleachable fluorescence of SWCNTs enables continuous analyte monitoring without decay in signal over time. The existence of multiple chiralities of SWCNTs emitting near-infrared fluorescence with narrow bandwidths allows a ratiometric signal readout invariant to the excitation source distance and exposure time. The individual fibers encapsulate the SWCNT nanosensors for at least 21 days without apparent loss in structural integrity. Moreover, the microfibrous textiles are utilized to spatially resolve peroxide concentrations using a camera and further integrated into commercial wound bandages without significant degradation in their optical properties.