Gold nanoparticles: enhanced optical trapping and sensitivity coupled with significant heating
Gold nanoparticles: enhanced optical trapping and sensitivity coupled with significant heating
复制标题
DOI：
10.1364/ol.31.002429
复制
发表时间：
2006-08-15
期刊：
影响因子：
3.6
通讯作者：
Perkins, Thomas T.
中科院分区：
文献类型：
--
作者：
Seol, Yeonee;Carpenter, Amanda E.;Perkins, Thomas T.
金纳米粒子似乎是光学捕获分析中的上级手柄。我们证明，相对较大的金颗粒（R-b = 50 nm）确实产生了六倍的捕获效率和检测灵敏度相比，类似大小的聚苯乙烯颗粒增强。然而，金在最常见的捕获波长（1064 nm）处的光吸收引起剧烈的加热（266摄氏度/瓦）。我们通过比较三种不同方法结合详细建模的陷阱刚度来确定这种加热。由于这种加热，金纳米颗粒对温度敏感的光学捕获实验没有用，但可以作为局部分子加热器。此外，这种颗粒，其增加的检测灵敏度，使某些零力生物物理测定的优秀探针。(c)2006年美国光学学会。
Gold nanoparticles appear to be superior handles in optical trapping assays. We demonstrate that relatively large gold particles (R-b = 50 nm) indeed yield a sixfold enhancement in trapping efficiency and detection sensitivity as compared to similar-sized polystyrene particles. However, optical absorption by gold at the most common trapping wavelength (1064 nm) induces dramatic heating (266 degrees C/W). We determined this heating by comparing trap stiffness from three different methods in conjunction with detailed modeling. Due to this heating, gold nanoparticles are not useful for temperature-sensitive optical-trapping experiments, but may serve as local molecular heaters. Also, such particles, with their increased detection sensitivity, make excellent probes for certain zero-force biophysical assays. (c) 2006 Optical Society of America.