Effects of stunting, diarrhoeal disease, and parasitic infection during infancy on cognition in late childhood: a follow-up study
Effects of stunting, diarrhoeal disease, and parasitic infection during infancy on cognition in late childhood: a follow-up study
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DOI：
10.1016/s0140-6736(02)07744-9
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发表时间：
2002-02-16
期刊：
影响因子：
168.9
通讯作者：
Black, MM
中科院分区：
文献类型：
--
作者：
Berkman, DS;Lescano, AG;Black, MM
背景婴儿期慢性营养不良，以发育迟缓为特征，与认知功能低下有关。我们评估的影响，发育迟缓，肠道疾病和寄生虫感染在婴儿期对认知功能在childhood.Methods我们随访了从出生到2年，一个队列的239名秘鲁儿童的人体测量，粪便样本，和肠道状况。在9岁时，我们评估了认知功能，在143（69%）与全面的韦氏儿童智力量表修订（WISC-R）的智商。结果所有的调查结果进行了调整的社会经济地位和学校教育，此外，腹泻患病率，贾第鞭毛虫，隐孢子虫的调查结果进行了调整严重发育迟缓。在生命的头2年，143名儿童中有46名（32%）发育不良。第二年严重发育迟缓的儿童在WISC-R测试中的得分比没有严重发育迟缓的儿童低10分（95%CI 2.4-17.5）。每年发生一次以上G lamblia的儿童得分比每年发生一次或更少的儿童低4.1分（0.2-8.0）。无论是腹泻的患病率，也不C parvum感染与WISC-R scores.Interpretation营养不良在幼儿期，索引的发育迟缓，并可能G Lamblia，与9岁时的认知功能差。如果观察到的关联是因果关系，那么旨在预防营养不良和格林巴利病的干预方案，在生命早期可能会导致整个欠发达世界类似低收入社区儿童认知功能的显着改善。
Background Chronic malnutrition during infancy, marked by stunting, has been associated with poor cognitive function. We assessed the effect of stunting, diarrhoeal disease, and parasitic infections during infancy on cognitive function in late childhood.Methods We followed up from birth to 2 years, a cohort of 239 Peruvian children for anthropometrics, stool samples, and diarrhoeal status. At 9 years of age, we assessed cognitive function in 143 (69%) with the full-scale intelligence quotient of the Wechsler intelligence scale for children-revised (WISC-R).Findings All findings were adjusted for socioeconomic status and schooling; in addition, findings related to diarrhoea prevalence, Giardia lamblia, and Cryptosporidium parvum were adjusted for severe stunting. During the first 2 years of life, 46 (32%) of 143 children were stunted. Children with severe stunting in the second year of life scored 10 points lower on the WISC-R test (95% CI 2.4-17.5) than children without severe stunting. Children with more than one episode of G lamblia per year scored 4.1 points (0.2-8.0) lower than children with one episode or fewer per year. Neither diarrhoea prevalence nor C parvum infection was associated with WISC-R scores.Interpretation Malnutrition in early childhood, indexed by stunting, and potentially G lamblia, are associated with poor cognitive function at age 9 years. If the observed associations are causal, then intervention programmes designed to prevent malnutrition and G lamblia, early in life could lead to significant improvement in cognitive function of children in similar lower-income communities throughout the less-developed world.