QT variability
QT variability
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DOI：
10.1016/j.jelectrocard.2003.09.019
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发表时间：
2003-01-01
影响因子：
1.3
通讯作者：
Berger, RD
中科院分区：
文献类型：
--
作者：
Berger, RD
我们假设，心室复极的暂时性不稳定是恶性室性心律失常风险增加的标志，并与其存在机械联系。为了评估体表心电图的复极不稳定性，我们开发了一种基于模板匹配的自动算法来测量QT间期的搏动变化。我们计算QT变异性指数(QTVI)来量化QT间期变化相对于心率变异性的相对大小。我们发现QTVI是一种可重复性的测量方法。在缺血性和非缺血性扩张型心肌病患者中，与年龄匹配的对照组相比，其水平升高(P<；.00001)。我们还发现，与肥厚型心肌病相关的恶性β-肌球蛋白重链突变患者的QTVI升高。在一项对接受电生理测试的患者的研究中，QTVI比电生理测试结果更好地识别心脏骤停患者，也比分析中包括的其他风险分层因素更好。QT变异性是脑室电病的标志，可能与威胁生命的心律失常风险增加有关。
We hypothesized that temporal lability in ventricular repolarization is a marker for, and is mechanistically related to, increased risk of malignant ventricular arrhythmias. To assess repolarization lability in the surface electrocardiogram, we developed an automated algorithm, based on template matching, to measure beat-to-beat changes in QT interval. We calculate a QT variability index (QTVI) to quantify the relative magnitude of QT interval changes compared to heart rate variability. We found that QTVI is a reproducible measure. It is elevated in patients with ischemic and nonischemic dilated cardiomyopathy compared with age-matched controls (P < .00001). We have also shown that QTVI is elevated in patients with malignant beta-myosin heavy-chain mutations associated with hypertrophic cardiomyopathy. In a study of patients undergoing electrophysiologic testing, QTVI identified patients with cardiac arrest better than electrophysiologic test result and better than other risk stratifiers included in the analysis. QT variability is a marker of electrical disease in the ventricle and may be associated with enhanced risk of life-threatening arrhythmias.