Nanomedicine—Challenge and Perspectives
Nanomedicine—Challenge and Perspectives
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DOI：
10.1002/chin.200914274
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发表时间：
2009-04
期刊：
影响因子：
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通讯作者：
K. Riehemann;Stefan W. Schneider;T. Luger;B. Godin;M. Ferrari;H. Fuchs
中科院分区：
文献类型：
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作者：
K. Riehemann;Stefan W. Schneider;T. Luger;B. Godin;M. Ferrari;H. Fuchs
纳米技术概念在医学中的应用将两个大型交叉学科领域结合起来，这两个领域具有前所未有的社会和经济潜力，这些潜力来自于各自领域具体成就的自然结合。共同的基础是从与这两个场相关的分子尺度性质发展而来的。局部探针和分子成像技术允许在预定义的位置在纳米尺度上表征表面和界面特性，而化学方法提供了精心制作和处理表面的机会，例如，用于靶向药物递送，增强生物相容性和神经假体目的。然而，在这一跨学科领域，人们对毒理学方面和伦理学方面的影响表示担忧。这篇综述概述了纳米医学的最新发展和应用。
The application of nanotechnology concepts to medicine joins two large cross‐disciplinary fields with an unprecedented societal and economical potential arising from the natural combination of specific achievements in the respective fields. The common basis evolves from the molecular‐scale properties relevant to the two fields. Local probes and molecular imaging techniques allow surface and interface properties to be characterized on a nanometer scale at predefined locations, while chemical approaches offer the opportunity to elaborate and address surfaces, for example, for targeted drug delivery, enhanced biocompatibility, and neuroprosthetic purposes. However, concerns arise in this cross‐disciplinary area about toxicological aspects and ethical implications. This Review gives an overview of selected recent developments and applications of nanomedicine.