Learned regulation of spatially localized brain activation using real-time fMRI
Learned regulation of spatially localized brain activation using real-time fMRI
复制标题
DOI：
10.1016/j.neuroimage.2003.08.041
复制
发表时间：
2004-01-01
期刊：
影响因子：
5.7
通讯作者：
Gabrieli, JDE
中科院分区：
文献类型：
--
作者：
DeCharms, RC;Christoff, K;Gabrieli, JDE
目前尚不清楚受试者是否能够通过神经成像学会自愿控制自己大脑局部区域的激活。在这里，我们表明，受试者能够学习到在选定的目标区域，即躯体运动皮层，对特定任务激活的增强自愿控制。在想象的手动动作任务中，研究人员为受试者提供了有关其认知过程的连续指导。受试者通过实时功能磁共振成像（rtfMRI）获得有关其当前感兴趣目标区域（ROI）激活水平的反馈信息，并收到自动调整激活水平的指令。信息以不断更新的图表形式提供，并使用简单的虚拟现实界面提供了激活水平的图像模拟。通过训练，受试者对大脑活动的控制得到了增强，这种控制与目标ROI（躯体运动皮层）的解剖学特异性有关。当提供基于rtfMRI的训练时，这种增强发生了，但在没有rtfMRI信息的情况下接受类似训练的对照组中没有这种增强，这表明这种效果不仅仅是由于传统的、基于实践的神经可塑性。训练后，单独使用认知过程，受试者可以在躯体运动皮层中有意识地诱导fMRI激活，其激活程度与实际运动中观察到的激活程度相当。经过训练的受试者在没有肌肉紧张的情况下增加了功能磁共振成像的激活，即使不再提供实时功能磁共振成像信息，他们也能够继续控制大脑的激活。这些结果表明，rtfMRI信息可用于指导认知过程，并且受试者能够学习有意识地调节解剖学目标大脑区域的激活，超越了训练前存在的任务驱动激活。(C) 2003 Elsevier Inc.版权所有。
It is not currently known whether subjects can learn to voluntarily control activation in localized regions of their own brain using neuroimaging. Here, we show that subjects were able to learn enhanced voluntary control over task-specific activation in a chosen target region, the somatomotor cortex. During an imagined manual action task, subjects were provided with continuous direction regarding their cognitive processes. Subjects received feedback information about their current level of activation in a target region of interest (ROI) derived using real-time functional magnetic resonance imaging (rtfMRI), and they received automatically-adjusted instructions for the level of activation to achieve. Information was provided both as continously upated graphs and using a simple virtual reality interface that provided an image analog of the level of activation. Through training, subjects achieved an enhancement in their control over brain activation that was anatomically specific to the target ROI, the somatomotor cortex. The enhancement took place when rtfMRI-based training was provided, but not in a control group that received similar training without rtfMRI information, showing that the effect was not due to conventional, practice-based neural plasticity alone. Following training, using cognitive processes alone subjects could volitionally induce fMRI activation in the somatomotor cortex that was comparable in magnitude to the activation observed during actual movement. The trained subjects increased fMRI activation without muscle tensing, and were able to continue to control brain activation even when real-time fMRI information was no longer provided. These results show that rtfMRI information can be used to direct cognitive processes, and that subjects are able to learn volitionally regulate activation in an anatomically-targeted brain region, surpassing the task-driven activation present before training. (C) 2003 Elsevier Inc. All rights reserved.