Oncocytic metaplasia in inflammatory fibrous hyperplasia: Histopathological and immunohistochemical analysis.
Oncocytic metaplasia in inflammatory fibrous hyperplasia: Histopathological and immunohistochemical analysis.
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炎性纤维增生中的嗜酸细胞化生：组织病理学和免疫组织化学分析。
DOI：
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发表时间：
2008
期刊：
影响因子：
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通讯作者：
P. Vargas
中科院分区：
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作者：
Ana Lúcia Carrinho Ayrosa Rangel;Jorge Esquiche León;J. Jorge;M. Lopes;P. Vargas
嗜酸细胞化生（OM）在炎症性纤维增生（IFH）病变中并不是一个众所周知的特征，尽管它可能很常见，正如我们以前关于这种病变的研究所提出的那样。在本文中，我们评估了18例IFH包含OM区的组织病理学和免疫组织化学特征。在苏木精和伊红染色切片上检查所有样本，并使用细胞角蛋白（AE 1/AE 3、34 β E12、CK 5、CK 7、CK 8、CK 13、CK 14和CK 19）、CD 15、CD 20、CD 68、CD 45 Ro和LCA一抗。绝大多数IFH发生在女性（n=14）中，最常见的发病部位是颊前庭。嗜酸细胞和唾液腺导管细胞对AE 1/AE 3、CK 7、CK 8和CK 19呈一致的免疫反应性。CD 45 Ro + T淋巴细胞是OM区域周围最常见的炎性细胞，其次是CD 20 + B淋巴细胞。提示IFH中的嗜酸细胞可能起源于涎腺导管上皮，T淋巴细胞在IFH的发病机制中可能起重要作用。
Oncocytic metaplasia (OM) is not a well-known feature in inflammatory fibrous hyperplasia (IFH) lesions, although it may be common, as proposed in our previous study about this lesion. In the present paper, we assessed the histopathological and immunohistochemical features of 18 cases of IFH containing OM areas. All the samples were examined on haematoxylin and eosin stained sections and cytokeratins (AE1/AE3, 34betaE12, CK5, CK7, CK8, CK13, CK14 and CK19), CD15, CD20, CD68, CD45Ro, and LCA primary antibodies were used. The vast majority of IFH occurred in women (n=14) and the most common site of presentation was the buccal vestibule. Oncocytic and salivary duct cells showed uniform immunoreactivity for AE1/AE3, CK7, CK8 and CK19. CD45Ro+ T-lymphocytes were the most common inflammatory cells surrounding the OM areas followed by CD20+ B-lymphocytes. These findings suggest that oncocytic cells present in IFH might develop from salivary duct epithelium, and T-lymphocytes might play an important role in its etiopathogenesis.