Multielectrode array recordings of bladder and perineal primary afferent activity from the sacral dorsal root ganglia
Multielectrode array recordings of bladder and perineal primary afferent activity from the sacral dorsal root ganglia
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DOI：
10.1088/1741-2560/8/5/056010
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发表时间：
2011-10-01
影响因子：
4
通讯作者：
Weber, Douglas J.
中科院分区：
文献类型：
--
作者：
Bruns, Tim M.;Gaunt, Robert A.;Weber, Douglas J.
膀胱和肠道神经假体的发展可能受益于感觉反馈的使用。我们评价了高密度穿透性微电极阵列在记录膀胱和会阴传入活动中的应用。在3只麻醉猫的S1和S2背根节内植入阵列。在调节膀胱容量的同时记录神经信号，并在会阴区域施加机械刺激。在两个实验中，观察到48个单位跟踪膀胱压力和它们的放电率(来自S2的79%)。在三个实验中的每个实验中，至少有50个额外的单位(总共274个；来自S2的60%)在一次或多次会阴刺激试验中，它们的放电率发生了显著变化。这项研究表明，在单个水平上设置一个骶骨背根神经节电极接口，从盆腔区域获取膀胱状态信息和其他反馈信号的可行性。这种自然的反馈来源对于提供膀胱或其他盆腔神经假体的闭环控制将是有价值的。
The development of bladder and bowel neuroprostheses may benefit from the use of sensory feedback. We evaluated the use of high-density penetrating microelectrode arrays in sacral dorsal root ganglia (DRG) for recording bladder and perineal afferent activity. Arrays were inserted in S1 and S2 DRG in three anesthetized cats. Neural signals were recorded while the bladder volume was modulated and mechanical stimuli were applied to the perineal region. In two experiments, 48 units were observed that tracked bladder pressure with their firing rates (79% from S2). At least 50 additional units in each of the three experiments (274 total; 60% from S2) had a significant change in their firing rates during one or more perineal stimulation trials. This study shows the feasibility of obtaining bladder-state information and other feedback signals from the pelvic region with a sacral DRG electrode interface located in a single level. This natural source of feedback would be valuable for providing closed-loop control of bladder or other pelvic neuroprostheses.