Effect of Antimicrobial Interventions on the Oral Microbiota Associated with Early Childhood Caries.
Effect of Antimicrobial Interventions on the Oral Microbiota Associated with Early Childhood Caries.
复制标题
DOI：
--
复制
发表时间：
2015-05
影响因子：
1.6
通讯作者：
Yihong Li;A. Tanner
中科院分区：
文献类型：
--
作者：
Yihong Li;A. Tanner
本系统性文献综述的目的是确定抗菌治疗方法对致龋菌群和幼儿龋齿（ECC）结局影响的研究证据;并回顾ECC临床研究中用于进行微生物评估的方法。方法检索多个数据库，仅选择1998 - 2014年发表的临床队列研究和随机对照试验。共识别出471个标题和摘要; 114项研究符合全面综述的纳入标准，其中41项研究被纳入荟萃分析。结果：在大多数回顾性研究中，致龋细菌水平（主要是变形链球菌（MS））在使用抗菌药物后中度降低，但一旦停止治疗，特别是在高危儿童中，就会发生细菌再生长和新的龋损。相对一致的研究结果表明，母亲的抗致龋微生物干预措施显着减少了儿童MS的获得。然而，缺乏对ECC预防的长期益处的研究。结论基于荟萃分析，抗菌干预和治疗显示MS定植水平暂时降低。然而，没有足够的证据表明所使用的方法对致龋微生物定植或ECC减少和预防产生可持续的影响。
PURPOSE The purposes of this systematic literature review were to identify research-based evidence for an effect of antimicrobial therapeutic approaches on the cariogenic microbiota and early childhood caries (ECC) outcomes; and to review methods used to perform microbial assessments in clinical studies of ECC. METHODS Multiple databases were searched; only clinical cohort studies and randomized controlled trials published from 1998 to 2014 were selected. A total of 471 titles and abstracts were identified; 114 studies met the inclusion criteria for a full review, from which 41 studies were included in the meta-analyses. RESULTS In most of the reviewed studies, moderate reductions in cariogenic bacterial levels, mainly in mutans streptococci (MS), were demonstrated following the use of antimicrobial agents, but bacterial regrowth occurred and new carious lesions developed once the treatment had ceased, particularly in high-risk children. Relatively consistent findings suggested that anti-cariogenic microbial interventions in mothers significantly reduced MS acquisition by children. However, studies of the long-term benefits of ECC prevention are lacking. CONCLUSION Based on the meta-analyses, antimicrobial interventions and treatments show temporary reductions in MS colonization levels. However, there is insufficient evidence to indicate that the approaches used produced sustainable effects on cariogenic microbial colonization or ECC reduction and prevention.