Fluoroquinolone antibiotics and adverse events.
Fluoroquinolone antibiotics and adverse events.
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氟喹诺酮抗生素和不良事件。
DOI：
10.18773/austprescr.2021.035
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发表时间：
2021-10
影响因子：
2.7
通讯作者：
Ananda-Rajah MR
中科院分区：
文献类型：
--
作者：
Baggio D;Ananda-Rajah MR
氟喹诺酮类药物是一种广谱抗生素，具有良好的口服生物利用度。它们被用于治疗各种各样的感染，但对这些药物的处方有限制。流行病学研究报告称，罕见不良反应的风险增加。这些包括肌腱病和肌腱断裂，周围神经病变和主动脉瘤。氟喹诺酮类药物的安全处方需要识别具有毒性风险因素的患者。如果发生不良反应，建议立即停药。只有在没有替代药物的情况下才开氟喹诺酮类药物，这也是限制不良事件和抗生素耐药性的关键。
Fluoroquinolones are broad-spectrum antibiotics with good oral bioavailability. They are used for the treatment of a wide variety of infections, but there are restrictions on prescribing these drugs. Epidemiological studies have reported an increased risk of rare adverse effects. These include tendinopathy and tendon rupture, peripheral neuropathy and aortic aneurysm. Safe prescribing of fluroquinolones requires recognition of patients with risk factors for toxicity. Prompt drug discontinuation is recommended in the event of an adverse reaction. Practising antimicrobial stewardship by prescribing fluoroquinolones only when alternative drugs are unavailable is also key to limiting adverse events and antibiotic resistance.