Comparative study of patients with and without SARS who fulfilled the who SARS case definition
Comparative study of patients with and without SARS who fulfilled the who SARS case definition
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DOI：
10.1016/j.jemermed.2004.11.022
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发表时间：
2005-05-01
影响因子：
1.5
通讯作者：
Lu, YT
中科院分区：
文献类型：
--
作者：
Chang, SM;Liu, CL;Lu, YT
为鉴别严重急性呼吸综合征(SARS)与非SARS疾病，我们对2003年4月27日至6月16日在麦凯纪念医院住院的53例疑似SARS患者和31例非SARS患者进行了回顾性比较。发烧(38摄氏度)是最早的症状(50/53sars vs.5131非sars，p<；0.0001)，平均在咳嗽之前4.5d。53例SARS患者中有22例胸片检查正常，5131例非SARS患者胸片检查正常。胸部X光检查初步正常的SARS患者在发烧后平均5+/-3.44天出现浸润性病变(21/22例SARS对015例非SARS患者)。24例SARS患者中有22例出现单灶性病变向多灶性浸润性病变的快速发展，而26例非SARS患者中仅有0例(P<；0.0001)。26例非SARS患者中有6例出现胸腔积液，但无一例出现胸腔积液(p<；0.0001)。最初的淋巴细胞减少、血小板减少和乳酸脱氢酶升高在SARS患者中都比非SARS患者更常见(p<；0.0001)。如果没有可靠和快速的诊断测试，它们可能有助于区分SARS和非SARS。(C)2005年爱思唯尔公司。
To differentiate severe acute respiratory syndrome (SARS) from non-SARS illness, we retrospectively compared 53 patients with probable SARS and 31 patients with non-SARS who were admitted to Mackay Memorial Hospital from April 27 to June 16, 2003. Fever (> 38 degrees C) was the earliest symptom (50/53 SARS vs. 5131 non-SARS, p < 0.0001), preceding cough by a mean of 4.5 days. The initial chest X-ray study was normal in 22/53 SARS cases versus 5131 non-SARS cases. SARS patients with an initially normal chest X-ray study developed infiltrates at a mean of 5 +/- 3.44 days after onset of fever (21/22 SARS vs. 015 non-SARS). Rapid radiographic progression of unifocal involvement to multifocal infiltrates was seen in 22 of 24 SARS vs. 0 of 26 non-SARS patients (p < 0.0001). Pleural effusion was not present in any SARS patients but was seen in 6 of 26 non-SARS cases (p < 0.0001). Initial lymphopenia, thrombocytopenia, and elevated lactate dehydrogenase were all more common in SARS than non-SARS (p < 0.0001). They may help differentiate SARS from non-SARS if a reliable and rapid diagnostic test is not available. (c) 2005 Elsevier Inc.