Intracellular signalling: PDK1 - a kinase at the hub of things
Intracellular signalling: PDK1 - a kinase at the hub of things
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DOI：
10.1016/s0960-9822(99)80058-x
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发表时间：
1999-02-11
期刊：
影响因子：
9.2
通讯作者：
Avruch, J
中科院分区：
文献类型：
--
作者：
Belham, C;Wu, SL;Avruch, J
磷酸肌醇依赖性激酶1（PDK1）是许多信号通路的中心，激活PKB和PKC同工酶，以及p70 S6激酶和PKA。PDK1的作用是由与底物的共定位和靶位点的可用性决定的，这些特征可以使其在静息和刺激细胞中发挥作用。
Phosphoinositide-dependent kinase 1 (PDK1) is at the hub of many signalling pathways, activating PKB and PKC isoenzymes, as well as p70 S6 kinase and perhaps PKA. PDK1 action is determined by colocalization with substrate and by target site availability, features that may enable it to operate in both resting and stimulated cells.