Circulating microRNAs as biomarkers for inflammatory diseases.
Circulating microRNAs as biomarkers for inflammatory diseases.
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循环 microRNA 作为炎症性疾病的生物标志物。
DOI：
10.2174/2211536611302010007
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发表时间：
2013
影响因子：
--
通讯作者：
Huang RS
中科院分区：
文献类型：
--
作者：
Mi S;Zhang J;Zhang W;Huang RS
MicroRNA（miRNAs）是一类具有基因调控功能的非编码小RNA分子，在多种疾病的发病机制中发挥着重要作用。目前的技术进步允许在不同组织中准确、高通量地分析miRNA丰度。最近，细胞外循环的miRNA已开始被证明是高度稳定的血液疾病生物标志物。了解循环miRNA和临床表型之间的相互作用可以增强我们对复杂疾病和特征的了解。另一方面，考虑到利用基于血液的生物标志物（例如，尽管在收集样品方面的便利性），作为生物标志物的循环miRNA可以改善疾病诊断和管理。特别是，我们回顾了最近的进展，确定循环miRNA作为几种常见的炎症性疾病，包括哮喘，炎症性肠病和类风湿性关节炎的生物标志物。目前的研究表明，使用循环miRNA治疗炎症性疾病具有广阔的前景。
MicroRNAs (miRNAs), a class of small, non-coding RNA molecules with gene regulatory functions, have emerged to play a critical role in the pathogenesis of a variety of diseases. Current technological advances allow accurate, high throughput profiling of miRNA abundance in different tissues. More recently, extracellular, circulating miRNAs have begun to be demonstrated as highly stable, blood-based biomarkers for diseases. Understanding the interactions between circulating miRNAs and clinical phenotypes can enhance our knowledge of complex diseases and traits. On the other hand, given the advantages of utilizing blood-based biomarkers (e.g., convenience in collecting samples), circulating miRNAs as biomarkers may improve both disease diagnosis and management. Particularly, we reviewed recent progress in identifying circulating miRNAs as biomarkers for several common inflammatory diseases including asthma, inflammatory bowel disease, and rheumatoid arthritis. Current studies showed a promising future of using circulating miRNAs in the care of inflammatory diseases.