Glucose, obesity, metabolic syndrome, and diabetes relevance to incidence of heart failure.
Glucose, obesity, metabolic syndrome, and diabetes relevance to incidence of heart failure.
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DOI：
10.1016/j.jacc.2009.07.029
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发表时间：
2010-01-26
影响因子：
24
通讯作者：
Fonarow, Gregg C.
中科院分区：
文献类型：
--
作者：
Horwich, Tamara B.;Fonarow, Gregg C.
心力衰竭 (HF) 很常见，导致临床结果不佳，并且与巨额医疗费用相关。心力衰竭的发病率持续上升，每年约有 670,000 例新病例，在美国 40 岁及以上的人中，心力衰竭的终生风险为 20%。心力衰竭的危险因素已经确定，因此预防策略应对疾病负担、发病率和死亡率产生积极影响。尽管冠状动脉疾病和高血压传统上被认为是心力衰竭最重要的可改变危险因素，但最近的研究强调了日益普遍的代谢危险因素（葡萄糖、糖尿病、肥胖和代谢综合征）的重要性。本文将提供血糖、糖尿病、肥胖、代谢综合征和心力衰竭之间联系的证据。此外，我们将讨论危险因素改变和其他预防性治疗如何有助于遏制心力衰竭发病率的上升。
Heart failure (HF) is common, results in poor clinical outcomes, and is associated with large health-care costs. The incidence of HF continues to rise, with approximately 670,000 new cases per year and a 20% lifetime risk of HF for persons 40 years and older in the United States. Risk factors for HF have been identified and thus preventative strategies should have a positive effect on disease burden, morbidity, and mortality. Although coronary artery disease and hypertension have traditionally been considered among the most important modifiable risk factors for the development of HF, recent studies have highlighted the importance of increasingly prevalent metabolic risk factors – glucose, diabetes, obesity, and the metabolic syndrome. This paper will present evidence for the link between glucose, diabetes, obesity, metabolic syndrome and incident HF. Furthermore, we will discuss how risk factor modification and other preventive therapies may help curb the rising incidence of HF.
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