Frequency specific resting state functional abnormalities in psychosis
Frequency specific resting state functional abnormalities in psychosis
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DOI：
10.1002/hbm.24302
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发表时间：
2018-11-01
影响因子：
4.8
通讯作者：
Szeszko, Philip R.
中科院分区：
文献类型：
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作者：
Gohel, Suril;Gallego, Juan A.;Szeszko, Philip R.
精神病的静息状态功能磁共振成像研究主要集中在血氧水平依赖（BOLD）信号范围从0.01到0.1 Hz的低频波动幅度上。然而，很少有研究调查离散频带内的频率波动幅度和高于0.1 Hz的精神病患者在不同的疾病阶段。我们研究了89例首发或慢性精神病患者和119名健康志愿者在三个频率范围内的BOLD信号，包括慢-4（.027-.073 Hz），慢-3（.074-0.198 Hz）和慢-2（0.199-0.25 Hz）。我们研究了三个频带内的频率波动的幅度，使用47个区域的利益放置在14个已知的静息态网络，使用组独立成分分析。视觉和运动皮层网络存在显著的组x频率相互作用，最大的显著组差异（患者<健康志愿者）分别在慢4和慢3中明显。此外，在视觉皮层、背侧注意和运动皮层网络的三个频率范围内，健康志愿者的频率波动幅度总体上高于患者，而在显著性和额回网络中则明显存在相反的效果（患者>健康志愿者）。随后的分析表明，这些影响在首次发作和慢性患者中都很明显。我们的研究提供了关于BOLD信号波动在精神病神经生物学中不同频带内的重要性的新数据。
Resting state functional magnetic resonance imaging studies of psychosis have focused primarily on the amplitude of low-frequency fluctuations in the blood oxygen level dependent (BOLD) signal ranging from .01 to 0.1 Hz. Few studies, however, have investigated the amplitude of frequency fluctuations within discrete frequency bands and higher than 0.1 Hz in patients with psychosis at different illness stages. We investigated BOLD signal within three frequency ranges including slow-4 (.027-.073 Hz), slow-3 (.074-0.198 Hz) and slow-2 (0.199-0.25 Hz) in 89 patients with either first-episode or chronic psychosis and 119 healthy volunteers. We investigated the amplitude of frequency fluctuations within three frequency bands using 47 regions-of-interest placed within 14 known resting state networks derived using group independent component analysis. There were significant group x frequency interactions for the visual and motor cortex networks, with the largest significant group differences (patients < healthy volunteers) evident in slow-4 and slow-3, respectively. Also, healthy volunteers had an overall higher amplitude of frequency fluctuations compared to patients across the three frequency ranges in the visual cortex, dorsal attention and motor cortex networks with the opposite effect (patients > healthy volunteers) evident within the salience and frontal gyrus networks. Subsequent analyses indicated that these effects were evident in both first-episode and chronic patients. Our study provides new data regarding the importance of BOLD signal fluctuations within different frequency bands in the neurobiology of psychosis.