The T cell receptor beta genes of Xenopus
The T cell receptor beta genes of Xenopus
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DOI：
10.1002/eji.1830270327
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发表时间：
1997-03-01
影响因子：
5.4
通讯作者：
DuPasquier, L
中科院分区：
文献类型：
--
作者：
Chretien, I;Marcuz, A;DuPasquier, L
T细胞受体β(TCRB)基因已从无尾两栖类非洲爪哇中分离得到，它们与其他脊椎动物的TCRB序列具有很强的结构同源性。到目前为止，已经定义了十个BV家族、两个D片段、十个J片段和一个C区。每个V家族每个单倍体基因组由一到两个成员组成。非洲爪哇TCRB恒定区的一个独特特征是缺乏N-连接的碳水化合物糖基化位点。重组信号序列表明，重排的机制与哺乳动物的相同。该基因座是以二倍体的方式遗传的，尽管本研究中使用的非洲爪哇和X.Gilli是假四倍体。
cDNA of the T cell receptor beta (TCRB) have been isolated from the anuran amphibian Xenopus and they show strong structural homology to TCRB sequences of other vertebrates. Ten BV families, two D segments, ten J segments, and a single C region have been defined so far. Each V family consists of one to two members per haploid genome. A unique feature of the Xenopus TCRB constant region is the lack of N-linked carbohydrate glycosylation sites. The recombination signal sequences suggest that the mechanism of rearrangements are identical to those of mammals. The locus is inherited in a diploid manner despite the pseudotetraploidy of the Xenopus laevis and X. gilli used in this study.