Effects of zinc on markers of glutamate and aspartate neurotransmission in rat hippocampus.
Effects of zinc on markers of glutamate and aspartate neurotransmission in rat hippocampus.
复制标题
锌对大鼠海马谷氨酸和天冬氨酸神经传递标志物的影响。
DOI：
10.1016/0006-8993(85)90219-7
复制
发表时间：
1985
期刊：
影响因子：
2.9
通讯作者：
Kasarskis,EJ
中科院分区：
文献类型：
--
作者：
Slevin,JT;Kasarskis,EJ
在断奶后维持限锌饮食的大鼠海马中，测量了受体结合和突触体对1 -[3H]谷氨酸和1 -[3H]天冬氨酸的摄取。尽管几乎是致命的锌缺乏，但与锌补充对照组相比，这些兴奋性氨基酸神经传递标志物未受影响。然而，体外添加锌明显抑制谷氨酸和天冬氨酸与海马膜的结合。这些数据表明锌可以调节受体对谷氨酸和天冬氨酸的亲和力，并可能在体内作为兴奋性突触的强直抑制剂。
Receptor binding and synaptosomal uptake ofl-[3H]glutamate andl-[3H]aspartate were measured in hippocampus derived from rats maintained on zinc restricted diets from weaning. Despite near lethal zinc deficiency, these markers of excitatory amino acid neurotransmission were unaffected compared to zinc-supplemented controls. However, addition of zinc in vitro markedly inhibited binding of glutamate and aspartate to hippocampal membranes. These data suggest that zinc can modulate the receptor affinities for glutamate and aspartate and may function as a tonic inhibitor of excitatory synapses in vivo.