Preliminary investigation of adherence to antiretroviral therapy among children in Aminu Kano Teaching Hospital, Nigeria.
Preliminary investigation of adherence to antiretroviral therapy among children in Aminu Kano Teaching Hospital, Nigeria.
复制标题
DOI：
10.2989/16085900609490374
复制
发表时间：
2006-09-01
期刊：
影响因子：
--
通讯作者：
Ladan, Zubaida Farouk
中科院分区：
文献类型：
--
作者：
Mukhtar-Yola, Mariya;Adeleke, Solomon;Ladan, Zubaida Farouk
使用高效抗逆转录病毒疗法（HAART）治疗艾滋病毒导致艾滋病毒相关疾病的发病率和死亡率下降，但对获取和坚持治疗的关注日益增加。为了确定在尼日利亚Aminu Kano教学医院传染病诊所就诊的儿童坚持抗逆转录病毒治疗的程度和不坚持抗逆转录病毒治疗的原因，对40名接受抗逆转录病毒治疗至少6个月的艾滋病毒感染儿童进行了一项使用自我报告工具的横断面研究。32名患者（80%）的药物依从性达到95%或以上。不坚持治疗的最常见原因是药品用完和由于财政限制而无法购买更多的药品；其他障碍是无法获得和无法获得药物。85%的儿科患者每天在同一时间服药，87.5%的患者遵守预定的预约。患者的社会阶层对依从性水平无显著影响。坚持抗逆转录病毒治疗的水平与其他发展中国家和发达国家报告的水平相当。抗逆转录病毒治疗的费用以及药物的可得性和可及性是坚持治疗的最大障碍。扩大获得补贴的抗逆转录病毒药物的机会应该改善资源贫乏环境中接受这种治疗的患者的依从性——从而改善治疗结果。
Treatment of HIV with highly active antiretroviral therapy (HAART) has resulted in declining morbidity and mortality rates from HIV-associated diseases, but concerns regarding access and adherence are growing. To determine the adherence level and the reasons for non-adhering to antiretroviral therapy (ART) among children attending the clinic for infectious diseases at Aminu Kano Teaching Hospital in Nigeria, a cross-sectional study using the selfreport tool was carried out among 40 children with HIV infection who had been on ART for at least six months. Thirty-two patients (80%) were 95% or more adherent to their medications. The most common reasons for nonadherence were running out of medicines and the inability to purchase more due to financial constraints; other barriers were non-availability and inaccessibility to medications. Eighty-five percent of the paediatric patients took their medications at the same time everyday, and scheduled appointments were kept by 87.5%. The social class of the patients did not significantly affect adherence level. The level of adherence to ART was comparable to levels reported from other developing and developed countries. The cost of ART, and availability and accessibility to medications were the most significant barriers to adherence. Expanded access to subsidised antiretroviral drugs should improve adherence - and consequently treatment outcomes - for patients receiving this treatment in resource-poor settings.