1,3,5,8-tetrahydroxyxanthone regulates ANGPTL3-LPL pathway to lessen the ketosis in mice.
1,3,5,8-tetrahydroxyxanthone regulates ANGPTL3-LPL pathway to lessen the ketosis in mice.
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DOI：
10.1016/j.ejps.2012.02.001
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发表时间：
2012-05
期刊：
影响因子：
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通讯作者：
Hong-Bo Xiao;Zhi-Liang Sun;N. Zhou
中科院分区：
文献类型：
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作者：
Hong-Bo Xiao;Zhi-Liang Sun;N. Zhou
酮症是一种与脂类和碳水化合物代谢密切相关的代谢紊乱。近年来的研究表明，血管生成素样蛋白3（ANGPTL 3）参与代谢紊乱的发生发展。本研究旨在探讨天然黄酮类化合物1，3，5，8-四羟基口山酮（Xan）对酮症的抑制作用及其调控机制。4周后，Xan（10或30 mg/kg，灌胃）治疗降低酮病小鼠的血浆总酮体、丙二醛、8-异前列烷、甘油三酯、总胆固醇水平和肝脏ANGPTL 3表达，同时升高血糖浓度和脂肪脂蛋白脂酶（LPL）表达。目前的结果表明，Xan调节ANGPTL 3-LPL通路，以减轻小鼠的酮症。
Ketosis is a metabolic disorder closely associated with both lipid and carbohydrate metabolism. Recent studies show that angiopoietin-like protein 3 (ANGPTL3) contributes to the development of metabolic disorder. The objective of this study was to explore the inhibitory effect of 1,3,5,8-tetrahydroxyxanthone (Xan), a naturally occurring flavonoid compound, on ketosis and the mechanisms involved in this regulation. After 4weeks, Xan (10 or 30mg/kg, intragastrically) treatment decreased plasma total ketone bodies, malondialdehyde, 8-isoprostane, triglyceride, total cholesterol levels, and hepatic ANGPTL3 expression concomitantly with increased plasma glucose concentration and adipose lipoprotein lipase (LPL) expression in ketosis murine. The present results suggest that Xan regulates ANGPTL3–LPL pathway to lessen the ketosis in mice.