Intentional cannabis use to reduce crack cocaine use in a Canadian setting: A longitudinal analysis
Intentional cannabis use to reduce crack cocaine use in a Canadian setting: A longitudinal analysis
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DOI：
10.1016/j.addbeh.2017.04.006
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发表时间：
2017-09-01
影响因子：
4.4
通讯作者：
Milloy, M-J
中科院分区：
文献类型：
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作者：
Socias, M. Eugenia;Kerr, Thomas;Milloy, M-J
背景：没有有效的药物治疗快克可卡因使用障碍。新出现的数据表明，大麻素可能在减少可卡因相关的渴望症状方面发挥作用。本研究调查故意使用大麻，以减少使用非法药物（PWUD）的人之间的裂纹使用。方法：数据来自三个前瞻性队列的PWUD在加拿大温哥华。使用来自报告故意使用大麻以控制快克使用的参与者的数据，我们使用广义线性混合效应模型来估计三个预定义的故意使用大麻时期（即，结果：在2012年至2015年期间，122名参与者报告使用大麻来减少可卡因使用，共提供了620个观察结果。在调整后的分析中，与治疗前相比，治疗后与裂缝使用频率降低相关（调整后比值比[AOR] = 1.89，95%置信区间[CI]：1.02-3.45），但与有意使用期无关（AOR = 0.85，95% CI：0.51-1.41）。后时期大麻使用频率高于前时期（AOR = 4.72，95%CI：2.47-8.99），并显示出频率低于故意使用大麻期间的趋势（AOR = 0.56，95% CI：0.32-1.01）。一段时间的故意使用大麻，以减少裂纹的使用与减少裂纹的使用频率在随后的时期之间的PWUD。进一步的临床研究，以评估大麻素治疗裂缝使用障碍的潜力是必要的。
Background: No effective pharmacotherapies exist for the treatment of crack cocaine use disorders. Emerging data suggests that cannabinoids may play a role in reducing cocaine-related craving symptoms. This study investigated the intentional use of cannabis to reduce crack use among people who use illicit drugs (PWUD).Methods: Data were drawn from three prospective cohorts of PWUD in Vancouver, Canada. Using data from participants reporting intentional cannabis use to control crack use, we used generalized linear mixed-effects modeling to estimate the independent effect of three pre-defined intentional cannabis use periods (i.e., before, during and after first reported intentional use to reduce crack use) on frequency of crack use.Results: Between 2012 and 2015, 122 participants reported using cannabis to reduce crack use, contributing a total of 620 observations. In adjusted analyses, compared to before periods, after periods were associated with reduced frequency of crack use (Adjusted Odds Ratio [AOR] = 1.89, 95% Confidence Interval [CI]: 1.02-3.45), but not the intentional use periods (AOR = 0.85, 95% CI: 0.51-1.41). Frequency of cannabis use in after periods was higher than in before periods (AOR = 4.72, 95% CI: 2.47-8.99), and showed a tendency to lower frequency than in intentional cannabis use periods (AOR = 0.56, 95% CI: 0.32-1.01).Conclusions: A period of intentional cannabis use to reduce crack use was associated with decreased frequency of crack use in subsequent periods among PWUD. Further clinical research to assess the potential of cannabinoids for the treatment of crack use disorders is warranted.