An extract of the medicinal mushroom Agaricus blazei Murill can protect against allergy.
An extract of the medicinal mushroom Agaricus blazei Murill can protect against allergy.
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药用蘑菇agaricus blazei murill的提取物可以预防过敏。
DOI：
10.1186/1476-7961-7-6
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发表时间：
2009-05-05
期刊：
影响因子：
--
通讯作者：
Hetland G
中科院分区：
文献类型：
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作者：
Ellertsen LK;Hetland G
Agaricus blazei Murill （AbM）是一种可食用的巴西蘑菇，在传统医学中用于治疗一系列疾病。它已被证明在小鼠中具有抗感染和抗肿瘤的特性，这是由于诱导Th1反应。另一方面，ige介导的过敏是由Th2反应引起的。由于根据Th1/Th2模式，Th1反应的增加可能促进Th2反应的减少，因此目的是检查AbM是否具有抗过敏作用。采用小鼠过敏模型，用模型过敏原卵清蛋白（OVA）免疫小鼠s.c.。此外，在免疫前1天或免疫后19天分别给予主要含AbM（82%）、猴头菌（15%）和灰树花（3%）的蘑菇提取物AndoSan™或PBS p.o.。第26天处死小鼠，检测血清中抗ova IgE （Th2应答）和IgG2a （Th1应答）抗体，脾细胞培养中检测Th1、Th2和Treg细胞因子。结果发现，AndoSan™提取物在卵细胞免疫前后均可降低小鼠的抗卵细胞IgE水平，但不能降低IgG2a水平。在AndoSan™组中，相对于Th1细胞因子水平，Th2有降低的趋势。这种特殊的AbM提取物既可以防止过敏的发展，也可以作为治疗物质对抗已建立的过敏。
Agaricus blazei Murill (AbM) is an edible Brazilian mushroom that has been used in traditional medicine for a range of diseases. It has been shown to have anti-infection and anti-tumor properties in the mouse, which are due to induction of Th1 responses. On the other hand, IgE-mediated allergy is induced by a Th2 response. Since according to the Th1/Th2 paradigm an increased Th1 response may promote a reduced Th2 response, the aim was to examine whether AbM had anti-allergy effects. A mouse model for allergy was employed, in which the mice were immunized s.c. with the model allergen ovalbumin (OVA). Additionally, the animals were given a mushroom extract, AndoSan™, mainly (82%) containing AbM, but also Hericium erinaceum (15%) and Grifola frondosa (3%), or PBS p.o. either a day before or 19 days after the immunization. The mice were sacrificed on day 26, and anti-OVA IgE (Th2 response) and IgG2a (Th1 response) antibodies were examined in serum and Th1, Th2 and Treg cytokines in spleen cells cultures. It was found that the AndoSan™ extract both when given either before or after OVA immunization reduced the levels of anti-OVA IgE, but not IgG2a, in the mice. There was a tendency to reduced Th2 relative to Th1 cytokine levels in the AndoSan™ groups. This particular AbM extract may both prevent allergy development and be used as a therapeutical substance against established allergy.