Taking aim at the extracellular matrix: CCN proteins as emerging therapeutic targets.
Taking aim at the extracellular matrix: CCN proteins as emerging therapeutic targets.
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DOI：
10.1038/nrd3599
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发表时间：
2011-12-01
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基质细胞蛋白质的CCN家族对于胚胎发育至关重要，并且在成人的炎症、伤口愈合和损伤修复中起重要作用。它们的表达或活性的失调有助于无数疾病的病理生物学，其中许多可能在炎症或组织损伤变成慢性时出现，包括纤维化、关节硬化、关节炎、糖尿病肾病和视网膜病以及癌症。新兴的研究表明，靶向CCN表达或信号传导途径在开发此类疾病的诊断和治疗方面具有前景。这篇综述总结了CCN蛋白的生物学，它们在各种病理中的作用，以及作为治疗靶点的潜力。
The CCN family of matricellular proteins is critical for embryonic development and plays important roles in inflammation, wound healing, and injury repair in the adult. Deregulation of their expression or activities contributes to the pathobiology of myriad diseases, many of which may arise when inflammation or tissue injury becomes chronic, including fibrosis, arthrosclerosis, arthritis, diabetic nephropathy and retinopathy, and cancer. Emerging studies indicate that targeting CCN expression or signaling pathways holds promise in the development of diagnostics and therapeutics for such diseases. This review summarizes the biology of CCN proteins, their roles in various pathologies, and potential as therapeutic targets.