Abnormal resting-state functional connectivity in posterior cingulate cortex of Parkinson's disease with mild cognitive impairment and dementia
Abnormal resting-state functional connectivity in posterior cingulate cortex of Parkinson's disease with mild cognitive impairment and dementia
复制标题
伴有轻度认知障碍和痴呆的帕金森病后扣带皮层静息态功能连接异常
DOI：
10.1111/cns.12838
复制
发表时间：
2018-10-01
影响因子：
5.5
通讯作者：
Pan, Xiao-Dong
中科院分区：
文献类型：
--
作者：
Zhan, Zhou-Wei;Lin, Li-Zhen;Pan, Xiao-Dong
目的采用静息态功能磁共振成像（RS-fMRI）研究帕金森病（PD）轻度认知障碍合并痴呆患者后扣带皮层（PCC）功能连接（FC）模式的变化。方法选取27例不同认知状态的PD患者和9例健康对照者（对照组）进行研究。 RS-功能磁共振成像。使用 DPARSF 和 REST 软件对 RS-fMRI 数据进行分析。通过基于种子的体素方法确定功能连接发生变化的区域，并在组之间进行比较。分析PD组FC强度与MoCA评分的相关性。结果参数图显示PD-MCI患者PCC功能连接统计性增加，PDD患者PCC功能连接减少。后一组患者还显示出前额皮质和小脑后部之间连接性增强的证据。 MoCA 评分与角回和小脑后部 PCC 连接强度之间存在显着正相关，而 MoCA 评分与所有其他脑区 PCC 连接强度之间存在负相关。结论当患者从 PD-NCI 过渡到 PD-MCI 时，PCC 中的功能连接似乎有所增加，表明皮质网络扩张。另一个新网络（补偿性前额皮质-小脑环）随后在从 PD-MCI 到 PDD 的过渡过程中形成。
ObjectiveTo investigate changes in the functional connectivity (FC) pattern in the posterior cingulate cortex (PCC) of Parkinson's disease (PD) patients with mild cognitive impairment and dementia by employing resting-state functional magnetic resonance imaging (RS-fMRI).MethodsTwenty-seven PD patients with different cognitive status and 9 healthy control subjects (control group) were enrolled for RS-fMRI. The RS-fMRI data were analyzed with DPARSF and REST software. Regions with changed functional connectivity were determined by the seed-based voxelwise method and compared between groups. Correlation between the intensity of FC and the MoCA scores of PD group was analyzed.ResultsParametric maps showed statistical increases in PCC functional connectivity in PD-MCI patients and decreases in PCC connectivity in PDD patients. The latter group of patients also showed evidence for increased connectivity between prefrontal cortices and posterior cerebellum. A significant positive correlation was found between the MoCA scores and the strength of PCC connectivity in the angular gyrus and posterior cerebellum and a negative correlation between MoCA scores and PCC connectivity in all other brain regions.ConclusionWhen patients transition from PD-NCI to PD-MCI, there appears to be an increase in functional connectivity in the PCC, suggesting an expansion of the cortical network. Another new network (a compensatory prefrontal cortical-cerebellar loop) later develops during the transition from PD-MCI to PDD.