Latest trends in ADHD drug prescribing patterns in children in the UK: prevalence, incidence and persistence.
Latest trends in ADHD drug prescribing patterns in children in the UK: prevalence, incidence and persistence.
复制标题
英国儿童的多动症药物处方模式的最新趋势：流行，发病率和持久性。
DOI：
10.1136/bmjopen-2015-010508
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发表时间：
2016-06-13
期刊：
影响因子：
2.9
通讯作者：
Smeeth L
中科院分区：
文献类型：
--
作者：
Beau-Lejdstrom R;Douglas I;Evans SJ;Smeeth L
调查1992年至2013年期间英国16岁以下儿童的注意力缺陷多动障碍（ADHD）药物处方。 所有在临床实践研究数据链（CPRD）中注册的16岁以下患者，观察时间至少为1年，并且在1992年1月1日至2013年12月31日期间接受过至少一次ADHD药物处方。计算了1995年至2013年期间儿童使用ADHD药物的患病率和发生率趋势，并估计了新用户的持续性。 16岁以下儿童中ADHD药物使用的患病率总体增加了34倍，从1995年的每10000名儿童1.5 95% CI（1.1至2.0）上升到2008年的每10000名儿童50.7 95% CI（49.2至52.1），然后稳定到2013年的每10000名儿童51.1 95% CI（49.7至52.6）。 新使用者的比率增加了8倍，2007年达到每10 000名儿童10.2 95% CI（9.5至10.9），2013年下降到每10 000名儿童9.1 95% CI（8.5至9.7）。 虽然1995年后流行率和发病率急剧上升，但这一趋势似乎从2008年起停止。我们发现，77%，95%CI（76%至78%）的儿童在1年后仍在接受治疗，60%，95%CI（59%至61%）在2年后。 从1992年到2008年左右，英国儿童使用ADHD药物的人数明显增加，此后使用水平稳定。与其他国家相比，英国儿童使用ADHD药物治疗的持续时间相对较长。
To investigate attention deficit and hyperactivity disorder (ADHD) drug prescribing in children under 16 years old in the UK between 1992 and 2013. All patients under 16 registered in the Clinical Practice Research Datalink (CPRD) with a minimum of 1 year of observation time and who received at least one prescription of any ADHD drug between 1 January 1992 and 31 December 2013.Trends in prevalence and incidence of use of ADHD drugs in children were calculated between 1995 and 2013 and persistence in new users was estimated. The prevalence of ADHD drug use in children under 16 increased 34-fold overall, rising from 1.5 95% CI (1.1 to 2.0) per 10 000 children in 1995 to 50.7 95% CI (49.2 to 52.1) per 10 000 children in 2008 then stabilising to 51.1 95% CI (49.7 to 52.6) per 10 000 children in 2013. The rate of new users increased eightfold reaching 10.2 95% CI (9.5 to 10.9) per 10 000 children in 2007 then decreasing to 9.1 95% CI (8.5 to 9.7) per 10 000 children in 2013. Although prevalence and incidence increased rather steeply after 1995, this trend seems to halt from 2008 onwards. We identified that 77%, 95% CI (76% to 78%) of children were still under treatment after 1 year and 60% 95% CI (59% to 61%) after 2 years. There was a marked increase in ADHD drug use among children in the UK from 1992 until around 2008, with stable levels of use since then. UK children show relatively long persistence of treatment with ADHD medications compared to other countries.