Antibiotic prophylaxis with meropenem after allogeneic stem cell transplantation
Antibiotic prophylaxis with meropenem after allogeneic stem cell transplantation
复制标题
同种异体干细胞移植后使用美罗培南进行抗生素预防
DOI：
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发表时间：
2004
影响因子：
4.8
通讯作者：
J. S. Miguel
中科院分区：
文献类型：
--
作者：
J. Pérez;I. Garcia;J. Martínez;L. Vázquez;D. Caballero;C. Cañizo;M. Mateos;J. S. Miguel
总结：在本研究中，我们分析了美罗培南在接受匹配亲属供者同种异体移植患者中的预防性疗效。总共有38名患者在第一次发热发作当天开始用美罗培南（n=17，A组）序贯治疗，而预防性美罗培南在第一天开始用<500/mm 3粒细胞（n=21，B组）治疗，并维持至发热消退或粒细胞计数>500/mm 3后。其中，A组16例（94%）患者出现发热，而B组16例（76%）患者出现发热（P=0.02）。虽然A组中只有1例患者不需要一线抗生素治疗，但B组中有7例（33%）患者不需要一线抗生素治疗（P=0.01），因为发热持续时间不到72 h。此外，B组中52%的患者不需要二线抗生素，而A组中11%的患者不需要二线抗生素（P=0.04）。在多变量分析中，美罗培南预防（HR=2.83，95% CI（1-8.02）; P=0.04）和移植时疾病状态（早期HR =0.15，95% CI（0.04-0.62）; P=0.04）显著影响发热的发生。总之，目前的初步研究表明，在接受同种异体移植的患者中性粒细胞减少期间使用美罗培南预防性治疗，通过减少发热事件，对手术的发病率产生有利影响。
Summary:In the present study, we analyze the efficacy of prophylaxis with meropenem in patients receiving a matched related donor allogeneic transplant. In total, 38 patients were sequentially treated with meropenem starting on the day of the first febrile episode (n=17, group A) vs prophylactic meropenem starting on the first day with <500/mm3 granulocytes (n=21, group B), and maintained until resolution of fever or after granulocyte count >500/mm3. Of these, 16 (94%) patients in group A developed fever as compared to 16 (76%) in group B (P=0.02). While only one patient in group A did not require first-line antibiotherapy, there were seven (33%) in group B who did not require it (P=0.01) since fever lasted less than 72 h. In addition, 52% patients in group B did not require second-line antibiotics as compared to 11% among patients in group A (P=0.04). In multivariate analysis prophylaxis with meropenem (HR=2.83, 95% CI (1–8.02); P=0.04) and disease status at transplant (HR for early stage=0.15, 95% CI (0.04–0.62); P=0.04) significantly influenced the development of fever. In conclusion, the current pilot study suggests that the use of prophylaxis with meropenem during the period of neutropenia in patients undergoing allogeneic transplantation favorably affects the morbidity of the procedure by reducing febrile episodes.
对大型国家医疗保健系统感染控制计划的调查。
DOI：
10.1086/523867
发表时间：
2007
期刊：
Infection control and hospital epidemiology : the official journal of the Society of Hospital Epidemiologists of America
影响因子：
--
作者：
Talbot,ThomasR;Tejedor,SheriChernetsky;Greevy,RobertA;Burgess,Hayley;Williams,MarkV;Deshpande,JayantK;McFadden,Patsy;Weinger,MatthewB;Englebright,Jane;Dittus,RobertS;Speroff,Theodore
通讯作者：
Speroff,Theodore
环丙沙星与甲氧苄啶/磺胺甲恶唑用于预防骨髓移植受者细菌感染：一项随机对照试验。
DOI：
10.1200/jco.1995.13.1.239
发表时间：
1995
期刊：
Journal of clinical oncology : official journal of the American Society of Clinical Oncology
影响因子：
--
作者：
Lew,MA;Kehoe,K;Ritz,J;Antman,KH;Nadler,L;Kalish,LA;Finberg,R
通讯作者：
Finberg,R
影响因子：
11.8
作者：
SABLE, CA;DONOWITZ, GR
通讯作者：
DONOWITZ, GR