Synthetic Porcine Hepcidin Exhibits Different Roles in Escherichia coli and Salmonella Infections
Synthetic Porcine Hepcidin Exhibits Different Roles in Escherichia coli and Salmonella Infections
复制标题
合成猪铁调素在大肠杆菌和沙门氏菌感染中表现出不同的作用
DOI：
10.1128/aac.02638-16
复制
发表时间：
2017-10-01
影响因子：
4.9
通讯作者：
Du, Hua-Hua
中科院分区：
文献类型：
--
作者：
Liu, Dan;Gan, Zhen-Shun;Du, Hua-Hua
Hepcidin, an antimicrobial peptide, was discovered to integrate diverse signals from iron status and an infection threat and orchestrate a series of host protective responses. Several studies have investigated the antimicrobial role of hepcidin, but the results have been controversial. Here, we aimed to examine the role of hepcidin in bacterial adherence and invasion in vitro. We found that porcine hepcidin could decrease the amount of the extracellular pathogen enterotoxigenic Escherichia coli (ETEC) K88 that adhered to cells because it caused the aggregation of the bacteria. However, addition of hepcidin to macrophages infected with the intracellular pathogen Salmonella enterica serovar Typhimurium enhanced the intracellular growth of the pathogen through the degradation of ferroportin, an iron export protein, and then the sequestration of intracellular iron. Intracellular iron was unavailable by use of the iron chelator deferiprone (DFO), which reduced intracellular bacterial growth. These results demonstrate that hepcidin exhibits different functions in extracellular and intracellular bacterial infections, which suggests that different defense strategies should be taken to prevent bacterial infection.
