Smaller anterior hippocampal formation volume in antipsychotic-naive patients with first-episode schizophrenia
Smaller anterior hippocampal formation volume in antipsychotic-naive patients with first-episode schizophrenia
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DOI：
10.1176/appi.ajp.160.12.2190
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发表时间：
2003-12-01
影响因子：
17.7
通讯作者：
Bilder, RM
中科院分区：
文献类型：
--
作者：
Szeszko, PR;Goldberg, E;Bilder, RM
目的：作者研究了首次发作的精神分裂症患者相对于健康对照受试者的前海马结构的体积变化。方法：从连续的 1.5 毫米冠状磁共振图像中，将海马结构分为后段和前段，并将前海马结构与杏仁核分离。研究人员计算了 46 名首次精神分裂症发作患者（31 名男性和 15 名女性）以及 34 名健康对照受试者（21 名男性和 13 名女性）的后海马结构和前海马结构以及杏仁核的体积。扫描时，24 名患者未接受过抗精神病药物治疗。 结果：相对于健康对照受试者，患者的总（右加左）前海马结构体积显着减小，但后海马结构或杏仁核的体积没有差异。当分析仅限于未接受过抗精神病药物治疗的患者亚组时，也得到了类似的结果。结论：这些结果表明，海马-杏仁核复合体的体积异常可能是精神分裂症首次发作患者前海马结构所特有的，并且与关于额叶连接异常在精神分裂症中发挥作用的假设是一致的。 该疾病的病理生理学。
Objective: The authors investigated volumetric alterations of the anterior hippocampal formation in patients experiencing a first episode of schizophrenia relative to healthy comparison subjects.Method: From contiguous 1.5-mm coronal magnetic resonance images, the hippocampal formation was divided into posterior and anterior segments, and the anterior hippocampal formation was separated from the amygdala. Volumes of the posterior and anterior hippocampal formation and amygdala were computed in 46 (31 male and 15 female) patients experiencing a first episode of schizophrenia and in 34 (21 male and 13 female) healthy comparison subjects. Twenty-four patients were antipsychotic naive at the time of the scan.Results: Patients had significantly reduced total (right plus left) anterior hippocampal formation volume relative to healthy comparison subjects but did not differ in volumes of either the posterior hippocampal formation or amygdala. Similar findings were obtained when analyses were restricted to the antipsychotic-naive subgroup of patients.Conclusions: These findings suggest that volumetric abnormalities of the hippocampus-amygdala complex may be specific to the anterior hippocampal formation in patients experiencing a first episode of schizophrenia and are consistent with hypotheses regarding abnormal frontolimbic connectivity playing a role in the pathophysiology of the disorder.