Lactobacillus plantarum PS128 alleviates neurodegenerative progression in 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-induced mouse models of Parkinson's disease
Lactobacillus plantarum PS128 alleviates neurodegenerative progression in 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-induced mouse models of Parkinson's disease
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DOI：
10.1016/j.bbi.2020.07.036
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发表时间：
2020-11-01
影响因子：
15.1
通讯作者：
Tsai, Ying-Chieh
中科院分区：
文献类型：
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作者：
Liao, Jian-Fu;Cheng, Yun-Fang;Tsai, Ying-Chieh
有证据表明，帕金森病（PD）的发病机制与微生物群-肠-脑轴（MGBA）中的双向通路密切相关，精神生物药可抑制PD进展。我们以前报道过，新的精神生物菌株，植物乳杆菌PS128（PS128），改善异常行为和调制的多巴胺能通路在啮齿动物模型中的神经传递。在这里，我们报告说，口服PS128 4周显着减轻运动障碍，皮质酮，黑质纹状体多巴胺能神经元死亡，纹状体多巴胺减少1-甲基-4苯基-1，2，3，6-四氢吡啶（MPTP）诱导的PD小鼠模型的升高。PS128摄入抑制胶质细胞过度活化，并增加PD模型小鼠纹状体中的去甲肾上腺素和神经营养因子。PS128给药还减弱了MPTP诱导的黑质纹状体途径中的氧化应激和神经炎症。粪便分析表明，PS128调节肠道微生物群。L.植物菌丰度与甲硫氨酸生物合成相关的微生物模块一起沿着显著增加。PS128还抑制MPTP引起的肠杆菌科和脂多糖和肽聚糖生物合成相关的微生物模块的增加。总之，PS128摄入减轻MPTP诱导的运动缺陷和神经毒性。补充PS128可抑制PD模型小鼠的神经退行性过程，并可能有助于预防PD。
Evidence suggests that the Parkinson's disease (PD) pathogenesis is strongly associated with bidirectional pathways in the microbiota-gut-brain axis (MGBA), and psychobiotics may inhibit PD progression. We previously reported that the novel psychobiotic strain, Lactobacillus plantarum PS128 (PS128), ameliorated ab normal behaviors and modulated neurotransmissions in dopaminergic pathways in rodent models. Here, we report that orally administering PS128 for 4 weeks significantly alleviated the motor deficits, elevation in corticosterone, nigrostriatal dopaminergic neuronal death, and striatal dopamine reduction in 1-methyl-4 phenyl-1,2,3,6-tetrathydropyridine (MPTP)-induced PD mouse models. PS128 ingestion suppressed glial cell hyperactivation and increased norepinephrine and neurotrophic factors in the striatum of the PD-model mice. PS128 administration also attenuated MPTP-induced oxidative stress and neuroinflammation in the nigrostriatal pathway. Fecal analysis showed that PS128 modulated the gut microbiota. L. plantarum abundance was significantly increased along with methionine biosynthesis-related microbial modules. PS128 also suppressed the increased family Enterobacteriaceae and lipopolysaccharide and peptidoglycan biosynthesis-related microbial modules caused by MPTP. In conclude, PS128 ingestion alleviated MPTP-induced motor deficits and neurotoxicity. PS128 supplementation inhibited neurodegenerative processes in PD-model mice and may help prevent PD.