Changes in hepatic levels of tyrosine aminotransferase messenger RNA during chemical hepatocarcinogenesis.
Changes in hepatic levels of tyrosine aminotransferase messenger RNA during chemical hepatocarcinogenesis.
复制标题
化学性肝癌发生过程中肝脏酪氨酸转氨酶信使 RNA 水平的变化。
DOI：
10.1016/0304-3835(84)90111-3
复制
发表时间：
1984
期刊：
影响因子：
9.7
通讯作者：
Chiu,JF
中科院分区：
文献类型：
--
作者：
Huang,DP;Maine,AB;Chiu,JF
3′-甲基-4-二甲氨基偶氮苯（3′-MDAB）可使大鼠肝脏酪氨酸氨基转移酶（达特）活性呈双相下降。达特活性在肝癌发生的后期下降到极低水平。达特活性与AFP水平呈负相关。癌前病变和肝癌组织中达特酶活性的高低反映达特mRNA的表达量。在化学致癌过程中，地塞米松增加了大鼠肝脏达特酶活性和达特mRNA的含量。
The activity of tyrosine aminotransferase (TAT) decreased biphasically in livers of rats fed 3′-methyl-4-dimethylaminoazobenzene (3′-MDAB). TAT activity decreased to an extremely low level at later stages of hepatocarcinogenesis. The activity of TAT is negatively correlated with α-fetoprotein (AFP) levels. The level of TAT enzyme activity in precancerous liver and hepatoma is a reflection of the amount of TAT mRNA. Dexamethasone increased the TAT enzyme activity and TAT mRNA concentration in rat livers during chemical carcinogenesis.