Calcium stores and synaptic plasticity
Calcium stores and synaptic plasticity
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DOI：
10.1016/s0143416002001999
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发表时间：
2002-11-01
期刊：
影响因子：
4
通讯作者：
Collingridge, GL
中科院分区：
文献类型：
--
作者：
Fitzjohn, SM;Collingridge, GL
众所周知，中央突触的化学传递是高度可塑性的；突触连接的强度可以因个别突触的活动而双向改变。突触效能的长期变化，包括增加和减少，被认为与神经系统的发育有关，以及在学习和成瘾期间对外部提示做出反应的持续变化。突触传递的其他较短的持续变化对中枢神经系统的正常功能也可能是重要的。钙动员是多种形式的可塑性中的重要一步，尽管从细胞外间隙进入神经元往往是可塑性变化的初始触发因素，但细胞内钙的释放在各种形式的突触可塑性中也发挥着重要作用。(C)2002爱思唯尔科学有限公司。保留所有权利。
Chemical transmission at central synapses is known to be highly plastic; the strength of synaptic connections can be modified bi-directionally as a result of activity at individual synapses. Long-term changes in synaptic efficacy, both increases and decreases, are thought to be involved in the development of the nervous system, and in ongoing changes in response to external cues such as during learning and addiction. Other, shorter lasting changes in synaptic transmission are also likely to be important in normal functioning of the CNS. Calcium mobilisation is an important step in multiple forms of plasticity and, although entry into neurones from the extracellular space is often the initial trigger for plasticity changes, release of calcium from intracellular stores also has an important part to play in a variety of forms of synaptic plasticity. (C) 2002 Elsevier Science Ltd. All rights reserved.