Do the ethanol metabolizing enzymes modify the relationship between alcohol consumption and blood pressure?
Do the ethanol metabolizing enzymes modify the relationship between alcohol consumption and blood pressure?
复制标题
DOI：
10.1097/00004872-200306000-00009
复制
发表时间：
2003-06-01
影响因子：
4.9
通讯作者：
Tanaka, H
中科院分区：
文献类型：
--
作者：
Saito, K;Yokoyama, J;Tanaka, H
背景一些横断面研究探讨了饮酒与血压之间的关系（酒精-血压关系）是否在不同乙醛脱氢酶-2（ALDH 2）基因型的个体中存在差异，但很少有研究探讨酒精脱氢酶-2（ADH 2）的相关性，并且这些研究产生了不一致的结果。我们研究了潜在的调制效应的ADH 2和ALDH 2基因型的酒精-BP的关系，在日本农村community.Methods和结果的横截面样本的研究对象是335个随机选择的男性，年龄在40-69岁，谁住在志草，日本农村县，在1999年或2000年。采用聚合酶链反应-限制性片段长度多态性（PCR-RFLP）方法检测ADH 2和ALDH 2基因多态性。ADH 2（1）/2（1）的频率（野生型），2（1）/2（2）（超活性杂合子）和2（2）/2（2）（超活纯合子）分别为8.4%、34.9%和56.7%; ALDH 2（1）/2（1）（野生型）、2（1）/2（2）（失活杂合子）和2（2）/2（2）（失活纯合子）的基因频率分别为52.8、40.9。和6.3%。多元线性回归分析显示，ADH 2（1）/2（1）的男性饮酒量与舒张压之间的关系显著强于ADH 2（1）/2（2）或2（2）/2（2）的男性（校正回归系数=0.0392，+ 1 g乙醇/周为0.0113 mmHg，斜率差异P = 0.018）。结论在日本农村人群中，ADH 2（1）/2（1）基因型男性的酒精-血压关系显著强于ADH 2（1）/2（2）或2（2）/2（2）基因型男性。这一发现与之前的一项研究结果正好相反。
Background Several cross-sectional studies have examined whether the relationship between alcohol consumption and blood pressure (alcohol-BP relationship) differs among individuals with different aldehyde dehydrogenase-2 (ALDH2) genotypes, but few studies have examined the association with alcohol dehydrogenase-2 (ADH2), and those have yielded inconsistent results. We examined the potential modulatory effects of ADH2 and ALDH2 genotypes on the alcohol-BP relationship in a cross-sectional sample of a Japanese rural community.Methods and results The study subjects were 335 randomly selected men aged 40-69 years, who lived in Shiso, a Japanese rural county, in 1999 or 2000. The genetic polymorphisms of ADH2 and ALDH2 were determined by polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) methods. The frequencies of ADH2(1)/2(1) (wild-type), 2(1)/2(2) (superactive heterozygotes), and 2(2)/2(2) (superactive homozygotes) were 8.4, 34.9 and 56.7%, respectively; and those of ALDH2(1)/2(1) (wild-type), 2(1)/2(2) (inactive heterozygotes), and 2(2)/2(2) (inactive homozygotes) were 52.8, 40.9. and 6.3%, respectively. A multiple linear regression analysis showed that the relationship between alcohol consumption and diastolic blood pressure was significantly stronger in men with ADH2(1)/2(1) than those with ADH2(1)/2(2) or 2(2)/2(2) (adjusted regression coefficient=0.0392 versus 0.0113 mmHg for + 1 g ethanol/week, P for difference in slope = 0.018). The strength of the alcohol-BP relationship was similar in all of the ALDH2 genotype groups.Conclusion The alcohol-BP relationship was significantly stronger in men with ADH2(1)/2(1) than in men with ADH2(1)/2(2) or 2(2)/2(2) in this Japanese rural population., This finding was exactly the opposite of what one previous study suggested.