Level of blood pressure and risk of myocardial infarction among treated hypertensive patients.
Level of blood pressure and risk of myocardial infarction among treated hypertensive patients.
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DOI：
10.1001/archinte.1992.00400150045008
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发表时间：
1992-03
影响因子：
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通讯作者：
L. McCloskey;B. Psaty;T. Koepsell;G. N. Aagaard
中科院分区：
文献类型：
--
作者：
L. McCloskey;B. Psaty;T. Koepsell;G. N. Aagaard
为了研究治疗血压水平与心肌梗死发病率之间的关系，我们对912名接受高血压标准临床治疗的健康维护组织成员进行了一项基于人群的病例对照研究。我们发现最近测量的舒张压与心肌梗死风险之间存在J形关系，84 mm Hg时发生心肌梗死的风险最低。在60 mm Hg时心肌梗死的相对危险度为2.07（95%置信区间，0.86 - 5.01），在100 mm Hg时为1.45（95%置信区间，1.02 - 2.06）。治疗后的收缩压与梗死风险呈线性关系。我们的结论是，高血压患者舒张压的最佳目标范围可能是84至90毫米汞柱。超出此范围的水平可能与心肌梗死风险增加有关。
To examine the association between the level of treated blood pressure and the incidence of myocardial infarction, we conducted a population-based case-control study of 912 members of a health maintenance organization who were receiving standard clinical treatment for hypertension. We found a J-shaped relationship between the most recently measured diastolic blood pressure and the risk of myocardial infarction, the lowest risk occurring at 84 mm Hg. The relative risk of myocardial infarction at 60 mm Hg was 2.07 (95% confidence interval, 0.86 to 5.01), and at 100 mm Hg, 1.45 (95% confidence interval, 1.02 to 2.06). Treated systolic pressure bore a linear relationship to the risk of infarction. We conclude that the optimum target range for diastolic blood pressure in hypertensive patients may be 84 to 90 mm Hg. Levels outside this range may be associated with increased risk of myocardial infarction.