A case of Sweet's syndrome following septic pulmonary emboli after high‐dose chemotherapy for advanced testicular cancer
A case of Sweet's syndrome following septic pulmonary emboli after high‐dose chemotherapy for advanced testicular cancer
复制标题
晚期睾丸癌大剂量化疗后并发脓毒性肺栓塞并发斯威特综合征一例
DOI：
10.1111/j.1442-2042.2006.01332.x
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发表时间：
2006
影响因子：
2.6
通讯作者：
M. Fujisawa
中科院分区：
文献类型：
--
作者：
I. Hara;T. Miura;K. Yamanaka;Kazushi Tanaka;Yuji Yamada;M. Fujisawa
摘要一名33岁男性晚期睾丸癌患者接受了大剂量化疗联合外周血干细胞移植。 粒细胞集落刺激因子（G-CSF）给药后，在面部、大腿和小腿发现多发性浸润性红斑。皮肤科医生诊断为G-CSF引起的Sweet综合征;因此停止G-CSF给药。当皮肤病变改善时，在外周静脉导管的注射部位发现静脉炎。患者随后突发左胸痛和呼吸困难。胸部电脑断层显示脓毒性肺栓塞（SPE）的特征性结果。患者接受万古霉素、氟康唑和甲磺酸帕珠沙星治疗。虽然Sweet综合征和SPE是罕见的疾病，但在对泌尿系恶性肿瘤进行化疗时必须考虑这些疾病的存在。
Abstract A 33‐year‐old man with advanced testicular cancer underwent high‐dose chemotherapy combined with peripheral blood stem cell transplantation. After administration of granulocyte colony‐stimulating factor (G‐CSF), multiple infiltrative erythema was identified on the face, thigh, and lower leg. A dermatologist diagnosed this as Sweet's syndrome caused by G‐CSF; consequently G‐CSF administration was stopped. When the skin lesions had improved, phlebitis was found at the injection site of the peripheral vein catheter. The patient then suffered from sudden left chest pain and dyspnea. Chest computed tomography showed the characteristic findings of septic pulmonary emboli (SPE). He was treated by the administration of vancomycin, fluconazole, and pazufloxacin mesilate. Although Sweet's syndrome and SPE are rare diseases, the presence of these diseases must be considered when performing chemotherapy for urological malignancy.