Connections between ApoE, sleep, and Aβ and tau pathologies in Alzheimer's disease.
Connections between ApoE, sleep, and Aβ and tau pathologies in Alzheimer's disease.
复制标题
阿尔茨海默病中载脂蛋白E、睡眠、Aβ和tau病理之间的联系。
DOI：
10.1172/jci171838
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发表时间：
2023-07-17
影响因子：
15.9
通讯作者：
Vassar, Robert
中科院分区：
文献类型：
--
作者：
Sadleir, Katherine R.;Vassar, Robert
In this issue of the JCI, Wang and colleagues investigate the relationship between sleep disturbances, an environmental risk factor for Alzheimer’s disease (AD), and the apolipoprotein 4 (APOEε4) allele, a strong genetic risk factor for AD. The authors subjected an amyloid mouse model expressing human APOE3 or APOE4, with and without human AD-tau injection, to sleep deprivation and observed that amyloid and tau pathologies were worsened in the presence of APOE4. Moreover, decreased microglial clustering and increased dystrophic neurites around plaques were observed in sleep-deprived APOE4 mice. In addition, aquaporin 4, important for clearing amyloid-β through the glymphatic system, was reduced and less polarized to astrocytic endfeet. These APOE4-induced changes caused alterations in sleep behavior during recovery from sleep deprivation, suggesting a feed-forward cycle of sleep disturbance and increased AD pathology that can further disrupt sleep in the presence of APOE4.
