Long-term recordings from afferent taste fibers.
Long-term recordings from afferent taste fibers.
复制标题
来自传入味觉纤维的长期记录。
DOI：
10.1016/j.physbeh.2003.08.009
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发表时间：
2003
影响因子：
2.9
通讯作者：
Bradley,RobertM
中科院分区：
文献类型：
--
作者：
Shimatani,Yuichi;Nikles,StefanA;Najafi,Khalil;Bradley,RobertM
味蕾的受体细胞的寿命约为10天，但不知道这些受体的反应特征是否在周转周期中发生变化。为了检查味觉细胞随时间的反应，将微机械聚酰亚胺筛电极阵列植入大鼠鼓索神经的切割端之间，然后通过电极阵列再生。长期稳定的记录从再生的单一传入纤维支配味蕾是可能的，使用这种技术长达21天。对来自同一纤维的味觉刺激的反应随时间而变化。的变化发生在响应的幅度和相对响应曲线，以四种化学刺激，NaCl，蔗糖，盐酸，盐酸奎宁。这些反应特征的变化被假设为是由于味蕾中的受体细胞转换时味觉受体细胞的变化而引起的。
The receptor cells of taste buds have a life span of about 10 days but it is not known if response characteristics of these receptors alter during the turnover cycle. To examine taste cell responses over time, a micromachined polyimide sieve electrode array was implanted between the cut ends of the rat chorda tympani nerve, which then regenerated through the electrode array. Long-term stable recordings from regenerated single afferent fibers innervating taste buds were possible using this technique for up to 21 days. Responses to taste stimuli recorded from the same fiber changed with time. The changes occurred in both the magnitude of response and the relative response profiles to four chemical stimuli, NaCl, sucrose, HCl, and quinine HCl. These changes in response characteristics were hypothesized to result from changes in the taste receptor cells as the receptor cells turnover in the taste buds.