A gold-nanodot-decorated hollow carbon nanosphere based nanoplatform for intracellular miRNA imaging in colorectal cancer cells
A gold-nanodot-decorated hollow carbon nanosphere based nanoplatform for intracellular miRNA imaging in colorectal cancer cells
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基于金纳米点装饰的空心碳纳米球纳米平台，用于结直肠癌细胞内 miRNA 成像
DOI：
10.1039/c9cc06674h
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发表时间：
2019
影响因子：
4.9
通讯作者：
Wang Zheng
中科院分区：
文献类型：
--
作者：
Xiao Heng;Fan Huiling;Xu Luming;Pei Zhiyin;Lei Shijun;Xu Jinglei;Xi Jiangbo;Wang Guobin;Wang Lin;Wang Zheng
我们报道了一种新的基于透明质酸包覆的金纳米点状中空碳纳米球(AuHCNS-HA)的生物功能化纳米平台，用于活细胞中的microRNA成像。重要的是，包被HA的纳米平台可以通过CD44受体介导的内吞作用内化到靶细胞中。可进一步应用于CD44阳性结直肠癌细胞的miR-21细胞内显像。
We report a new biofunctionalized nanoplatform based on hyaluronic acid-coated gold-nano-dot-decorated hollow carbon nanospheres (AuHCNs-HA) for microRNA imaging in living cells. Importantly, the HA-coated nanoplatform could be internalized into target cells via CD44 receptor-mediated endocytosis. It can be further applied for intracellular miR-21 imaging in CD44-positive colorectal cancer cells.