Persistence of immunoglobulin M or immunoglobulin G antibody responses to Borrelia burgdorferi 10-20 years after active lyme disease
Persistence of immunoglobulin M or immunoglobulin G antibody responses to Borrelia burgdorferi 10-20 years after active lyme disease
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DOI：
10.1086/322669
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发表时间：
2001-09-15
影响因子：
11.8
通讯作者：
Steere, AC
中科院分区：
文献类型：
--
作者：
Kalish, RA;McHugh, G;Steere, AC
对多年前患有莱姆病的患者的血清学结果的解释还没有很好的定义。我们研究了79名10-20年前患有莱姆病的患者的血清学状态，这些患者目前没有活动性莱姆病的体征或症状。在40例单独患有早期莱姆病的患者中，4例（10%）目前对伯氏疏螺旋体有IgM反应，10例（25%）仍对螺旋体有IgG反应，这是通过2-测试方法（酶联免疫吸附试验和蛋白质印迹法）确定的。在39名患有莱姆关节炎的患者中，6名（15%）目前有IgM反应，24名（62%）仍然对螺旋体有IgG反应。对B的IgM或IgG抗体应答。莱姆病可能持续10-20年，但这些反应并不表明活动性感染。
The interpretation of serological results for patients who had Lyme disease many years ago is not well defined. We studied the serological status of 79 patients who had had Lyme disease 10-20 years ago and did not currently have signs or symptoms of active Lyme disease. Of the 40 patients who had had early Lyme disease alone, 4 (10%) currently had IgM responses to Borrelia burgdorferi, and 10 (25%) still had IgG reactivity to the spirochete, as determined by a 2-test approach (enzyme-linked immunosorbent assay and Western blot). Of the 39 patients who had had Lyme arthritis, 6 (15%) currently had IgM responses and 24 (62%) still had IgG reactivity to the spirochete. IgM or IgG antibody responses to B. burgdorferi may persist for 10-20 years, but these responses are not indicative of active infection.