Autophagy in Cancer Therapy.
Autophagy in Cancer Therapy.
复制标题
DOI：
10.3389/fonc.2017.00128
复制
发表时间：
2017
影响因子：
4.7
通讯作者：
Fulda S
中科院分区：
文献类型：
--
作者：
Fulda S
自噬是一种通过溶酶体降解细胞成分的分解代谢过程。它有助于减轻细胞应激并提供代谢前体，特别是在饥饿时。因此，自噬可以支持癌细胞的存活。此外，现在有令人信服的证据表明，在某些条件下，自噬也可以促进细胞死亡。自噬的这种双重功能也与抗癌治疗相关，因为许多化疗剂参与自噬。更好地了解介导癌细胞自噬细胞死亡的分子机制将有助于选择性地干扰这种细胞程序，以增加癌细胞对细胞毒性药物的反应。本文综述了抗癌药物诱导的自噬如何参与介导细胞死亡。
Autophagy represents a catabolic program involved in the degradation of cellular components via lysosomes. It serves to mitigate cellular stress and to provide metabolic precursors especially upon starvation. Thereby, autophagy can support the survival of cancer cells. In addition, there is now convincing evidence showing that under certain conditions autophagy can also foster cell death. This dual function of autophagy is also relevant upon anticancer treatment, as many chemotherapeutic agents engage autophagy. A better understanding of the molecular mechanisms that are critical for mediating autophagic cell death in cancer cells will be instrumental to selectively interfere with this cellular program in order to increase the cancer cell’s response to cytotoxic drugs. This review illustrates how anticancer drug-induced autophagy is involved in mediating cell death.