Using a polygenic score in a family design to understand genetic influences on musicality.
Using a polygenic score in a family design to understand genetic influences on musicality.
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DOI：
10.1038/s41598-022-18703-w
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发表时间：
2022-08-29
影响因子：
4.6
通讯作者：
Mosing, Miriam A.
中科院分区：
文献类型：
--
作者：
Wesseldijk, Laura W.;Abdellaoui, Abdel;Gordon, Reyna L.;Ullen, Fredrik;Mosing, Miriam A.
为了进一步了解音乐性的遗传学，我们探索了自我报告的节拍同步能力（PGSRythm）的多基因得分与客观测量的节奏辨别力以及其他经验证的音乐技能和音乐相关特征之间的关联。利用家系数据，我们能够进一步探索直接遗传、间接遗传（通过被动基因-环境相关）和混杂效应（如群体结构和选择性交配）的潜在途径。在5648对瑞典双胞胎中，我们发现PGSRythm不仅可以预测节奏辨别，还可以预测旋律和音高辨别（betas在0.11和0.16之间，p < 0.001），以及其他与音乐相关的结果（p < 0.05）。与此相反，PG节律与不直接与音乐相关的对照表型无关。协会没有恶化的家庭内（N = 243），这意味着间接的遗传或混杂效应没有膨胀PGSrhythm的影响。家庭儿童环境中音乐的丰富程度与个人的PG S节律之间存在相关性（r = 0.05，p < 0.001），表明基因-环境相关。我们的结论是，PG节奏捕捉个人的一般遗传音乐倾向，更可能直接影响音乐行为，而不是通过间接或混杂的影响。
To further our understanding of the genetics of musicality, we explored associations between a polygenic score for self-reported beat synchronization ability (PGSrhythm) and objectively measured rhythm discrimination, as well as other validated music skills and music-related traits. Using family data, we were able to further explore potential pathways of direct genetic, indirect genetic (through passive gene–environment correlation) and confounding effects (such as population structure and assortative mating). In 5648 Swedish twins, we found PGSrhythm to predict not only rhythm discrimination, but also melody and pitch discrimination (betas between 0.11 and 0.16, p < 0.001), as well as other music-related outcomes (p < 0.05). In contrast, PGSrhythm was not associated with control phenotypes not directly related to music. Associations did not deteriorate within families (N = 243), implying that indirect genetic or confounding effects did not inflate PGSrhythm effects. A correlation (r = 0.05, p < 0.001) between musical enrichment of the family childhood environment and individuals' PGSrhythm, suggests gene–environment correlation. We conclude that the PGSrhythm captures individuals' general genetic musical propensity, affecting musical behavior more likely direct than through indirect or confounding effects.
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影响因子：
4.5
作者：
Allegrini AG;Karhunen V;Coleman JRI;Selzam S;Rimfeld K;von Stumm S;Pingault JB;Plomin R
通讯作者：
Plomin R
DOI：
10.1093/bioinformatics/btz633
发表时间：
2020-02-01
期刊：
Bioinformatics (Oxford, England)
影响因子：
--
作者：
Lam M;Awasthi S;Watson HJ;Goldstein J;Panagiotaropoulou G;Trubetskoy V;Karlsson R;Frei O;Fan CC;De Witte W;Mota NR;Mullins N;Brügger K;Lee SH;Wray NR;Skarabis N;Huang H;Neale B;Daly MJ;Mattheisen M;Walters R;Ripke S
通讯作者：
Ripke S
影响因子：
30.8
作者：
Bulik-Sullivan, Brendan K.;Loh, Po-Ru;Finucane, Hilary K.;Ripke, Stephan;Yang, Jian;Patterson, Nick;Daly, Mark J.;Price, Alkes L.;Neale, Benjamin M.
通讯作者：
Neale, Benjamin M.
影响因子：
7.2
作者：
Belsky, Daniel W.;Harden, K. Paige
通讯作者：
Harden, K. Paige
DOI：
10.1037/0096-1523.27.2.411
发表时间：
2001-04-01
影响因子：
2.1
作者：
Madison, G
通讯作者：
Madison, G