Processing of food stimuli is selectively enhanced during insulin-related hypoglycemia in healthy mem
Processing of food stimuli is selectively enhanced during insulin-related hypoglycemia in healthy mem
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DOI：
10.1016/j.psyneuen.2004.12.006
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发表时间：
2005-06-01
影响因子：
3.7
通讯作者：
Born, J
中科院分区：
文献类型：
--
作者：
Schultes, B;Peters, A;Born, J
最近有报道称，在胰岛素诱导的低血糖症期间，选择性注意力指向食物刺激，这表明了一种自适应认知策略，以逃避这种潜在危险的代谢状态。在这里，我们使用短期记忆任务来测试这一假设。我们还旨在定义一个低血糖阈值水平，在该水平下，这种适应性认知策略首次发生。对15名健康男性进行了逐步降糖（血糖：4.1-3.6-3.1-2.6 mmol/l）和正葡萄糖钳夹实验。在交叉设计中以单盲方式进行夹闭，受试者之间的顺序平衡。在钳夹期间，在基线和每个低血糖平台以及正常血糖钳夹的相应时间间隔进行认知功能测试（食物相关和非食物相关词语的短期回忆; Stroop任务）。所有认知功能测试的表现在低血糖期间与眼虫钳夹相比均恶化（均P < 0.02）。在每个低血糖平台期的单独分析显示，基线和轻度低血糖期间食物和非食物相关的短期记忆相似。然而，在2.6 mmol/l的低血糖目标水平下，与正常血糖控制钳夹条件相比，食物相关词的回忆率高于非食物相关词（p=0.024）。在最低血糖水平（2.6 mmol/l）时，单词-颜色冲突Stroop任务的表现首先显著受损，而在较高血糖水平（3.6和3.1 mmol/l）时，Stroop子测试“颜色命名”和“单词阅读”的表现已经受损。分别）。总的来说，Stroop任务的数据表明，通过执行机制控制注意力对胰岛素诱导的低血糖的敏感性低于预先注意的自动刺激处理（阅读，命名）。如果注意力的执行控制受到低血糖的影响，认知资源似乎优先分配给食物刺激的处理。(c)2005爱思唯尔有限公司保留所有权利。
Recently it has been reported that during insulin-induced hypoglycemia selective attention is directed to food stimuli suggesting an adaptive cognitive strategy to escape from this potentially dangerous metabolic state. Here, we tested this hypothesis using a short-term memory task. We also aimed to define a hypoglycemic threshold level at which such an adaptive cognitive strategy first occurs. Fifteen healthy men underwent stepwise hypoglycemic (plasma glucose: 4.1-3.6-3.1-2.6 mmol/l) and euglycemic clamp experiments. Clamps were performed in a single blind fashion within a cross-over design with the order balanced across subjects. During the clamps cognitive function tests (short-term recall of food-related and non-food-related words; Stroop task) were applied at baseline and each hypoglycemic plateau, and at the corresponding time intervals of the euglycemic clamp. Performance on all cognitive function tests applied deteriorated during the hypoglycemic as compared to the euglcemic clamp (all P < 0.02). Separate analyses at each hypoglycemic plateau revealed that food and non-food related short-term memory was similar during baseline and mild hypoglycemia. However, at the hypoglycemic target level of 2.6 mmol/l, recall of food related words was higher than non-food related words when compared to the euglycemic control clamp condition (p=0.024). Performance on the word-color conflict Stroop task became significantly impaired first at the lowest hypoglycemic plateau (2.6 mmol/l), while performance on the Stroop subtests 'color naming' and 'word reading' were already impaired at higher plasma glucose levels (3.6 and 3.1 mmol/l.; respectively). Collectively, data of the Stroop task indicate that the control of attention via executive mechanisms is less sensitive to insulin-induced hypoglycemia than preattentive automated stimulus processing (reading, naming). If executive control of attention becomes affected by hypoglycemia, cognitive resources appear to be preferentially allocated to the processing of food stimuli. (c) 2005 Elsevier Ltd. All rights reserved.