Applications of circulating tumor cells for prostate cancer.
Applications of circulating tumor cells for prostate cancer.
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DOI：
10.1016/j.ajur.2016.09.004
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发表时间：
2016-10
影响因子：
2.6
通讯作者：
Posadas EM
中科院分区：
文献类型：
--
作者：
Cheng S;Chen JF;Lu YT;Chung LWK;Tseng HR;Posadas EM
临床医生面临的主要挑战之一是准确监测疾病进展的困难。前列腺癌是这些疾病中的一种，极大地影响了全球男性的健康。循环肿瘤细胞(CTCs)是一种从原发肿瘤脱落并进入外周循环的罕见的癌细胞群体。直到最近，CTC的临床应用还仅限于在肿瘤学中使用计数作为一种预后工具。然而，新兴的CTC技术的进步指向了可能给前列腺癌领域带来革命性变化的新应用。现在可以根据形态表型、生化分析和基因组图谱，将CTCs作为液体活检的组成部分进行研究。这些进展使我们能够深入了解癌症生物学的异质性和动力学，并进一步研究治疗耐药性演变背后的机制。将CTC用于临床应用的这些最新发展将极大地影响前列腺癌研究的未来，并为男性个性化护理铺平道路。
One of the major challenges that clinicians face is in the difficulties of accurately monitoring disease progression. Prostate cancer is among these diseases and greatly affects the health of men globally. Circulating tumor cells (CTCs) are a rare population of cancer cells that have shed from the primary tumor and entered the peripheral circulation. Not until recently, clinical applications of CTCs have been limited to using enumeration as a prognostic tool in Oncology. However, advances in emerging CTC technologies point toward new applications that could revolutionize the field of prostate cancer. It is now possible to study CTCs as components of a liquid biopsy based on morphological phenotypes, biochemical analyses, and genomic profiling. These advances allow us to gain insight into the heterogeneity and dynamics of cancer biology and to further study the mechanisms behind the evolution of therapeutic resistance. These recent developments utilizing CTCs for clinical applications will greatly impact the future of prostate cancer research and pave the way towards personalized care for men.