Interpregnancy Weight Change and Risk for Adverse Perinatal Outcome
Interpregnancy Weight Change and Risk for Adverse Perinatal Outcome
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DOI：
10.1097/aog.0b013e3182a7f63e
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发表时间：
2013-11-01
影响因子：
7.2
通讯作者：
Devlieger, Roland
中科院分区：
文献类型：
--
作者：
Bogaerts, Annick;Van den Bergh, Bea R. H.;Devlieger, Roland
目的：研究解释性体重变化与不良母婴结局风险之间的关系。弗兰德斯2009年至2011年期间，在妊娠21-42周时分娩的前两胎连续分娩的所有活产单胎分娩（比利时北方地区）和纳入围产期流行病学研究中心数据库的患者（N= 7，897）。妊娠间体重变化计算为第一次妊娠的孕前体重指数（BMI）与第二次妊娠的孕前BMI之间的差异。多因素Logistic回归分析预测妊娠期糖尿病、妊娠高血压综合征、剖宫产、巨大儿（4，000 g或以上），低出生体重（小于2，500 g）和先天性畸形进行检查。结果：妊娠期糖尿病的调整优势比（OR）为2.25（95%可信区间[CI] 1.33-3.78; P=.002），妊娠高血压综合征的校正OR为3.76（95% CI 2.16-6.57; P
OBJECTIVE: To examine the association between interpregnancy weight change and the risk for adverse maternal and neonatal outcomes.METHODS: All live-born singleton births delivered at 21-42 weeks of gestation in women who had their first two consecutive births between 2009 and 2011 in Flanders (the northern part of Belgium) and who were included in the Study Center for Perinatal Epidemiology database (N=7,897) were included. Interpregnancy weight change was calculated as the difference between the prepregnancy body mass index (BMI) of the first pregnancy and the prepregnancy BMI of the second pregnancy. Multivariate logistic regression analysis to predict gestational diabetes mellitus, pregnancy-induced hypertension, cesarean delivery, macrosomia (4,000 g or greater), low birth weight (less than 2,500 g), and congenital malformations were performed.RESULTS: The adjusted odds ratio (OR) for gestational diabetes mellitus was 2.25 (95% confidence interval [CI] 1.33-3.78; P=.002) for interpregnancy weight retention of 2 or more BMI units, and the adjusted OR for pregnancy-induced hypertension was 3.76 (95% CI 2.16-6.57; P