Psychological distress in long-term survivors of solid tumors diagnosed in childhood: A report from the childhood cancer survivor study
Psychological distress in long-term survivors of solid tumors diagnosed in childhood: A report from the childhood cancer survivor study
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DOI：
10.1002/pbc.20914
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发表时间：
2007-07-01
影响因子：
3.2
通讯作者：
Zeltzer, Lonnie K.
中科院分区：
文献类型：
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作者：
Zebrack, Brad J.;Zevon, Michael A.;Zeltzer, Lonnie K.
目的。评估和比较儿童时期确诊的实体瘤长期存活者及其兄弟姐妹的心理痛苦，并找出心理痛苦的显著相关因素。程序。在儿童时期被诊断为实体肿瘤的成年幸存者(2778人)和2925名兄弟姐妹完成了一份长期随访问卷，评估与抑郁、躯体化和焦虑相关的症状，以及人口统计、健康和医疗信息。结果。总体而言，绝大多数兄弟姐妹和幸存者报告的心理痛苦症状很少，如果有的话。总体而言，与兄弟姐妹相比，实体肿瘤幸存者报告的简明症状清单(BSI-I 8)衡量的全球痛苦水平显著更高，以及更高的躯体化和焦虑水平。然而，与人口标准相比，幸存者和兄弟姐妹报告的全球和维度痛苦程度较低。女性、较低的教育和收入水平、被认为健康状况不佳以及对当前健康问题的报告都与报告幸存者和兄弟姐妹的心理痛苦症状有关。在幸存者中，截肢与报告的全局和维度痛苦症状较少有关。结论。健康状况差、收入、教育和就业水平低似乎是实体肿瘤幸存者痛苦的预测因素。因此，促进健康并促进教育进步、获得收入和社会互动的干预措施，以最大限度地减少孤立和最大限度地提供社会支持，可能会减少儿童癌症幸存者的心理痛苦，提高生活质量。
Purpose. To evaluate and compare psychological distress in long-term survivors of solid tumors diagnosed in childhood and their siblings, and to identify significant correlates of psychological distress. Procedure. Adult survivors (2,778) of solid tumors diagnosed in childhood and 2,925 siblings completed a long-term follow-up questionnaire assessing symptoms associated with depression, somatization, and anxiety, as well as demographic, health, and medical information. Results. Overall, a large majority of siblings and survivors reported few, if any, symptoms of psychological distress. In the aggregate, solid tumor cancer survivors reported significantly higher levels of global distress as measured by the Brief Symptom Inventory (BSI-I 8), as well as higher levels of somatization and anxiety, when compared to siblings. However, when compared to population norms, both survivors and siblings reported lower levels of global and dimensional distress. Female gender, lower educational and income attainment, perceived poor health status and reports of current health problems all were associated with reporting psychological distress symptoms for both survivors and siblings. Among survivors, having a limb amputation was associated with reporting fewer symptoms of global and dimensional distress. Conclusion. Poor health status, low levels of income, education, and employment appear to be predictors of distress for survivors of solid tumors. Thus, interventions that promote health and facilitate educational advancement, income attainment and social interaction to minimize isolation and maximize social support may reduce psychological distress and promote quality of life for childhood cancer survivors.