The action of oncogenes in the cytoplasm and nucleus.
The action of oncogenes in the cytoplasm and nucleus.
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癌基因在细胞质和细胞核中的作用。
DOI：
10.1126/science.2997917
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发表时间：
1985
期刊：
影响因子：
--
通讯作者：
Weinberg,RA
中科院分区：
文献类型：
--
作者：
Weinberg,RA
迄今为止，已经鉴定了多达40种不同的病毒和细胞起源的癌基因。这些基因中的许多基因可以根据它们对细胞表型的影响而分为功能类。这些分组提示了癌基因编码蛋白的少量作用机制。一些数据表明，在细胞质中，这些蛋白质可以调节关键的第二信使分子的水平;在细胞核中，这些蛋白质可以调节细胞转录机制的活性。许多基因产物也可能与决定细胞对生长刺激因子反应的信号通路有关。由于这些基因中的一些在非生长的分化细胞中表达，因此编码的蛋白质可能在某些组织中介导与细胞生长控制无关的功能。
As many as 40 distinct oncogenes of viral and cellular origin have been identified to date. Many of these genes can be grouped into functional classes on the basis of their effects on cellular phenotype. These groupings suggest a small number of mechanisms of action of the oncogene-encoded proteins. Some data suggest that, in the cytoplasm, these proteins may regulate levels of critical second messenger molecules; in the nucleus, these proteins may modulate the activity of the cell's transcriptional machinery. Many of the gene products can also be related to a signaling pathway that determines the cell's response to growth-stimulating factors. Because some of these genes are expressed in nongrowing, differentiated cells, the encoded proteins may in certain tissues mediate functions that are unrelated to cellular growth control.